FAM89B Antibody (PACO16307)
- SKU:
- PACO16307
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | FAM89B Antibody (PACO16307) |
| Antibody SKU: | PACO16307 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:200-1:1000, IHC:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Fusion protein of human FAM89B |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO16307(FAM89B Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
 | Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Mouse liver tissue, Primary antibody: PACO16307(FAM89B Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO16307(FAM89B Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | Mtvr1 (mammary tumor virus receptor homolog 1), also known as FAM89B (family with sequence similarity 89, member B), is a 176 amino acid, protein that exists as two alternatively spliced isoforms. Belonging to the FAM89 family, Mtvr1 is encoded by a gene that maps to human chromosome 11, which comprises approximately 4% of human genomic DNA and is considered a gene and disease association dense chromosome. The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double strand DNA breaks. Atm mutation leads to the disorder known as ataxia-telangiectasia. The blood disorders Sickle cell anemia and thalassemia are caused by HBB gene mutations, while Wilms' tumors, WAGR syndrome and Denys-Drash syndrome are associated with mutations of the WT1 gene. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11-encoded genes. |
| Synonyms: | family with sequence similarity 89, member B |
| UniProt Protein Function: | FAM89B: Belongs to the FAM89 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Receptor, misc.Chromosomal Location of Human Ortholog: 11q13Cellular Component: cell surface; cytoplasmBiological Process: negative regulation of transforming growth factor beta receptor signaling pathway |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q8N5H3 |
| NCBI GenInfo Identifier: | 149192858 |
| NCBI Gene ID: | 23625 |
| NCBI Accession: | NP_001092255.1 |
| UniProt Secondary Accession: | Q8N5H3,Q6PJ27, E9PB01, E9PL72 |
| UniProt Related Accession: | Q8N5H3 |
| Molecular Weight: | 15,391 Da |
| NCBI Full Name: | protein FAM89B isoform 1 |
| NCBI Synonym Full Names: | family with sequence similarity 89, member B |
| NCBI Official Symbol: | FAM89B |
| NCBI Official Synonym Symbols: | MTVR; MTVR1; LRAP25 |
| NCBI Protein Information: | protein FAM89B |
| UniProt Protein Name: | Protein FAM89B |
| UniProt Synonym Protein Names: | |
| Protein Family: | |
| UniProt Gene Name: | FAM89B |
| UniProt Entry Name: | FA89B_HUMAN |
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