FAM35AFAM35/B Antibody (PACO22523)
- SKU:
- PACO22523
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | FAM35AFAM35/B Antibody (PACO22523) |
| Antibody SKU: | PACO22523 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| Species Reactivity: | Human |
| Immunogen: | Synthesized peptide derived from internal of human FAM35A/B. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from Jurkat cells, using FAM35A/B antibody. |
| Background: | Belongs to the FAM35 family. 2 isoforms of the human protein are produced by alternative splicing. |
| Synonyms: | Protein FAM35A; Protein FAM35B; |
| UniProt Protein Function: | Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs) (PubMed:29656893, PubMed:29789392). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection (PubMed:29656893, PubMed:29789392). Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres (PubMed:29656893). |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q86V20 |
| NCBI GenInfo Identifier: | 1052785544 |
| NCBI Gene ID: | 54537 |
| NCBI Accession: | NP_001317041.1 |
| UniProt Secondary Accession: | Q86V20,O95885, Q9H991 |
| UniProt Related Accession: | Q86V20 |
| Molecular Weight: | 94 KD |
| NCBI Full Name: | shieldin complex subunit 2 isoform 1 |
| NCBI Synonym Full Names: | shieldin complex subunit 2 |
| NCBI Official Symbol: | SHLD2 |
| NCBI Official Synonym Symbols: | RINN2; FAM35A; FAM35A1; bA163M19.1 |
| NCBI Protein Information: | shieldin complex subunit 2; protein FAM35A |
| UniProt Protein Name: | Shieldin complex subunit 2 |
| UniProt Synonym Protein Names: | Protein FAM35A |
| Protein Family: | |
| UniProt Gene Name: | SHLD2 |
| UniProt Entry Name: |
| Antibodies |
| FAM35A Antibody (PACO04646) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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