FAM134B Antibody (PACO49302)
- SKU:
- PACO49302
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | FAM134B Antibody (PACO49302) |
| Antibody SKU: | PACO49302 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Reticulophagy receptor FAM134B protein (1-131AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human pancreatic tissue using PACO49302 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human skin tissue using PACO49302 at dilution of 1:100. |
| Background: | Endoplasmic reticulum-anchored autophagy receptor that mediates ER delivery into lysosomes through sequestration into autophagosomes. Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the fragments into autophagosomes via interaction with ATG8 family proteins. Required for long-term survival of nociceptive and autonomic ganglion neurons. |
| Synonyms: | Reticulophagy regulator 1 (Reticulophagy receptor 1), RETREG1, FAM134B JK1 |
| UniProt Protein Function: | |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a cis-Golgi transmembrane protein that may be necessary for the long-term survival of nociceptive and autonomic ganglion neurons. Mutations in this gene are a cause of hereditary sensory and autonomic neuropathy type IIB (HSAN IIB), and this gene may also play a role in susceptibility to vascular dementia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011] |
| UniProt Code: | Q9H6L5 |
| NCBI GenInfo Identifier: | 21361617 |
| NCBI Gene ID: | 54463 |
| NCBI Accession: | NP_061873 |
| UniProt Secondary Accession: | Q9H6L5 |
| UniProt Related Accession: | Q9H6L5 |
| Molecular Weight: | 39kDa |
| NCBI Full Name: | reticulophagy regulator 1 isoform 2 |
| NCBI Synonym Full Names: | reticulophagy regulator 1 |
| NCBI Official Symbol: | RETREG1 |
| NCBI Official Synonym Symbols: | JK1; JK-1; FAM134B |
| NCBI Protein Information: | reticulophagy regulator 1 |
| UniProt Protein Name: | Protein FAM134B |
| UniProt Synonym Protein Names: | |
| Protein Family: | |
| UniProt Gene Name: | FAM134B |
| UniProt Entry Name: | F134B_HUMAN |
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