FAM111A Antibody (PACO50914)
- SKU:
- PACO50914
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | FAM111A Antibody (PACO50914) |
| Antibody SKU: | PACO50914 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Protein FAM111A protein (26-179AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human liver cancer using PACO50914 at dilution of 1:100. |
 | Immunofluorescent analysis of HepG2 cells using PACO50914 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Chromatin-associated protein required for PCNA loading on replication sites. Promotes S-phase entry and DNA synthesis. May directly function at replication forks, explaining why Simian virus 40 (SV40) interacts with FAM111A to overcome host range restriction. |
| Synonyms: | Protein FAM111A, FAM111A, KIAA1895 |
| UniProt Protein Function: | FAM111A: Belongs to the FAM111 family.Protein type: Unknown functionChromosomal Location of Human Ortholog: 11q12.1Cellular Component: cytoplasm; nucleus; chromatinMolecular Function: protein binding; catalytic activityBiological Process: negative regulation of viral genome replication; viral reproduction; DNA replication; defense response to virusDisease: Kenny-caffey Syndrome, Type 2; Gracile Bone Dysplasia |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is cell-cycle regulated, and has nuclear localization. The C-terminal half of the protein shares homology with trypsin-like peptidases and it contains a PCNA-interacting peptide (PIP) box, that is necessary for its co-localization with proliferating cell nuclear antigen (PCNA). Reduced expression of this gene resulted in DNA replication defects, consistent with the demonstrated role for this gene in Simian Virus 40 (SV40) viral replication. Mutations in this gene have been associated with Kenny-Caffey syndrome (KCS) type 2 and the more severe osteocraniostenosis (OCS, also known as Gracile Bone Dysplasia), both characterized by short stature, hypoparathyroidism, bone development abnormalities, and hypocalcemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015] |
| UniProt Code: | Q96PZ2 |
| NCBI GenInfo Identifier: | 215983094 |
| NCBI Gene ID: | 63901 |
| NCBI Accession: | NP_001135991.1 |
| UniProt Secondary Accession: | Q96PZ2,Q5RKS9, Q5XKM2, Q68DK9, Q6IPR7, Q9H5Y1, A8K5Y8 |
| UniProt Related Accession: | Q96PZ2 |
| Molecular Weight: | 70,196 Da |
| NCBI Full Name: | protein FAM111A |
| NCBI Synonym Full Names: | family with sequence similarity 111, member A |
| NCBI Official Symbol: | FAM111A |
| NCBI Official Synonym Symbols: | KCS2; GCLEB |
| NCBI Protein Information: | protein FAM111A |
| UniProt Protein Name: | Protein FAM111A |
| UniProt Synonym Protein Names: | |
| Protein Family: | Protein |
| UniProt Gene Name: | FAM111A |
| UniProt Entry Name: | F111A_HUMAN |
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