F11 Antibody (PACO26597)

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SKU:
PACO26597
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
Applications:
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated

Description

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Antibody Name:F11 Antibody (PACO26597)
Antibody SKU:PACO26597
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, IHC
Recommended Dilutions:ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:Human
Immunogen:Recombinant Human Coagulation factor XI protein (19-387AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageImmunohistochemistry of paraffin-embedded human liver tissue using PACO26597 at dilution of 1:100.
Background:Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.
Synonyms:Coagulation factor XI (FXI) (EC 3.4.21.27) (Plasma thromboplastin antecedent) (PTA) [Cleaved into: Coagulation factor XIa heavy chain; Coagulation factor XIa light chain], F11
UniProt Protein Function:F11: Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX. Defects in F11 are the cause of factor XI deficiency (FA11D); also known as plasma thromboplastin antecedent deficiency or Rosenthal syndrome. It is a hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate. Belongs to the peptidase S1 family. Plasma kallikrein subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Protease; Secreted, signal peptide; EC 3.4.21.27; Secreted

Chromosomal Location of Human Ortholog: 4q35

Cellular Component: extracellular region; extracellular space; plasma membrane

Molecular Function:protein binding

Biological Process: blood coagulation, intrinsic pathway; plasminogen activation; positive regulation of fibrinolysis

Disease: Factor Xi Deficiency

NCBI Summary:This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq, Jul 2008]
UniProt Code:P03951
NCBI GenInfo Identifier:119762
NCBI Gene ID:2160
NCBI Accession:P03951.1
UniProt Secondary Accession:P03951,Q4W5C2, Q9Y495, D3DP64,
UniProt Related Accession:P03951
Molecular Weight:63,840 Da
NCBI Full Name:Coagulation factor XI
NCBI Synonym Full Names:coagulation factor XI
NCBI Official Symbol:F11  
NCBI Official Synonym Symbols:FXI  
NCBI Protein Information:coagulation factor XI
UniProt Protein Name:Coagulation factor XI
UniProt Synonym Protein Names:Plasma thromboplastin antecedent; PTA
Protein Family:Coagulation factor
UniProt Gene Name:F11  
UniProt Entry Name:FA11_HUMAN
ELISA Kits
Human Factor XI / F11 ELISA Kit
Human F11 (Coagulation Factor XI) CLIA Kit (HUES00480)
Human F11 (Coagulation Factor XI) ELISA Kit (HUES01907)
Human Coagulation factor XI (F11) ELISA Kit
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
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