EXPH5 Antibody (PACO46918)
- SKU:
- PACO46918
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | EXPH5 Antibody (PACO46918) |
| Antibody SKU: | PACO46918 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Exophilin-5 protein (1235-1490AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human lung tissue using PACO46918 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human melanoma using PACO46918 at dilution of 1:100. |
| Background: | May act as Rab effector protein and play a role in vesicle trafficking. |
| Synonyms: | Exophilin-5 (Synaptotagmin-like protein homolog lacking C2 domains b) (SlaC2-b) (Slp homolog lacking C2 domains b), EXPH5, KIAA0624 SLAC2B |
| UniProt Protein Function: | exophilin 5: May act as Rab effector protein and play a role in vesicle trafficking. 2 isoforms of the human protein are produced by alternative splicing.Protein type: GAPs; GAPs, RabChromosomal Location of Human Ortholog: 11q22.3Cellular Component: endosomeMolecular Function: Rab GTPase bindingBiological Process: intracellular protein transport; positive regulation of protein secretion; positive regulation of exocytosisDisease: Epidermolysis Bullosa, Nonspecific, Autosomal Recessive |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a member of the synaptotagmin-like protein (Slp) family lacking a C2 domain. It contains an N-terminal synaptotagmin-like homology domain (SHD), and is a ras-related protein Rab-27B effector protein. This protein is thought to be involved in exosome secretion and intracellular vesicle trafficking. Reduced expression of this gene results in keratin filament defects. Mutations in this gene have been associated with some cases of epidermolysis bullosa, an inherited skin fragility disorder. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015] |
| UniProt Code: | Q8NEV8 |
| NCBI GenInfo Identifier: | 296439360 |
| NCBI Gene ID: | 23086 |
| NCBI Accession: | Q8NEV8.3 |
| UniProt Secondary Accession: | Q8NEV8,Q2KHM1, Q9Y4D6 |
| UniProt Related Accession: | Q8NEV8 |
| Molecular Weight: | 222,519 Da |
| NCBI Full Name: | Exophilin-5 |
| NCBI Synonym Full Names: | exophilin 5 |
| NCBI Official Symbol: | EXPH5 |
| NCBI Official Synonym Symbols: | SLAC2B; SLAC2-B |
| NCBI Protein Information: | exophilin-5; slp homolog lacking C2 domains b; synaptotagmin-like homologue lacking C2 domains b; synaptotagmin-like protein homolog lacking C2 domains b |
| UniProt Protein Name: | Exophilin-5 |
| UniProt Synonym Protein Names: | Synaptotagmin-like protein homolog lacking C2 domains b; SlaC2-b; Slp homolog lacking C2 domains b |
| Protein Family: | Exophilin |
| UniProt Gene Name: | EXPH5 |
| UniProt Entry Name: | EXPH5_HUMAN |
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