EWS Antibody (PACO21454)
- SKU:
- PACO21454
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | EWS Antibody (PACO21454) |
| Antibody SKU: | PACO21454 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:1000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Peptide sequence around aa.213~217(T-Y-G-Q-P)derived from Human EWS. |
| Form: | Liquid |
| Storage Buffer: | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from 293 and 3T3 cells using EWS Antibody. |
| Background: | This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14. |
| Synonyms: | bK984G1.4; EWSR1; |
| UniProt Protein Function: | |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9BZD1 |
| NCBI GenInfo Identifier: | 74761352 |
| NCBI Gene ID: | 0 |
| NCBI Accession: | Q9BZD1 |
| UniProt Secondary Accession: | Q9BZD1 |
| UniProt Related Accession: | Q9BZD1 |
| Molecular Weight: | 51,917 Da |
| NCBI Full Name: | Ewings sarcoma EWS-Fli1 (Type 1) oncogene |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | |
| UniProt Protein Name: | Ewings sarcoma EWS-Fli1 (Type 1) oncogene |
| UniProt Synonym Protein Names: | Ewings sarcoma EWS-Fli1 (Type 1) oncogene |
| Protein Family: | |
| UniProt Gene Name: | |
| UniProt Entry Name: | Q9BZD1_HUMAN |
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