ETV6 Transcription Factor Activity Assay
- SKU:
- TFAB00100
- Product Type:
- ELISA Kit
- ELISA Type:
- Transcription Factor Assay
- Analytes:
- ETV6
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
Description
system_update_altDatasheet
| Product Name: | ETV6 Transcription Factor Activity Assay |
| Product Code: | TFAB00100 |
| Target: | ETV6 |
| Synonyms: | ETS translocation variant 6, ETS-related protein Tel1, Tel |
| Reactivity: | Human, Mouse, Rat |
| Sample Types: | Nuclear or cell lysates |
The Assay Genie ETV6 transcription factor activity assay allows for the detection and qualitative analysis of endogenous levels of activated transcription factors in a variety of nuclear and cell lysates
Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.
| Assay Time: | 4.5 hours |
| Detection Method: | Colorimetric 450 nm |
| Size: | 12 x 8-Well Microstrips |
| Storage: | 4°C for 6 months |
| UniProt Protein Function: | Tel: Transcriptional repressor; binds to the DNA sequence 5'- CCGGAAGT-3'. A chromosomal aberration involving ETV6 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;12)(q33;p13) with PDGFRB. It is characterized by abnormal clonal myeloid proliferation and by progression to acute myelogenous leukemia (AML). Chromosomal aberrations involving ETV6 are found in a form of acute myeloid leukemia (AML). Translocation t(12;22)(p13;q11) with MN1; translocation t(4;12)(q12;p13) with CHIC2. Chromosomal aberrations involving ETV6 are found in childhood acute lymphoblastic leukemia (ALL). Translocations t(12;21)(p12;q22) and t(12;21)(p13;q22) with RUNX1/AML1. A chromosomal aberration involving ETV6 is found in a form of pre-B acute myeloid leukemia. Translocation t(9;12)(p24;p13) with JAK2. A chromosomal aberration involving ETV6 is found in myelodysplastic syndrome (MDS) with basophilia. Translocation t(5;12)(q31;p13) with ACSL6. A chromosomal aberration involving ETV6 is found in acute eosinophilic leukemia (AEL). Translocation t(5;12)(q31;p13) with ACSL6. A chromosomal aberration involving ETV6 is found in myelodysplastic syndrome (MDS). Translocation t(1;12)(p36.1;p13) with MDS2. Defects in ETV6 are a cause of myeloproliferative disorder chronic with eosinophilia (MPE). A hematologic disorder characterized by malignant eosinophils proliferation. A chromosomal aberration involving ETV6 is found in many instances of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;12) with PDGFRB on chromosome 5 creating an ETV6-PDGFRB fusion protein. Defects in ETV6 are a cause of acute myelogenous leukemia (AML). AML is a malignant disease in which hematopoietic precursors are arrested in an early stage of development. A chromosomal aberration involving ETV6 is found in acute lymphoblastic leukemia. Translocation t(9;12)(p13;p13) with PAX5. Belongs to the ETS family. |
| UniProt Protein Details: | Protein type:Transcription factor; Oncoprotein; Motility/polarity/chemotaxis; DNA-binding Chromosomal Location of Human Ortholog: 12p13 Cellular Component: cytoplasm; nucleolus; nucleus Molecular Function:protein binding; protein domain specific binding; transcription factor activity Biological Process: cell differentiation; negative regulation of transcription from RNA polymerase II promoter Disease: Thrombocytopenia 5 |
| NCBI Summary: | This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma. [provided by RefSeq, Sep 2008] |
| UniProt Code: | P41212 |
| NCBI GenInfo Identifier: | 730927 |
| NCBI Gene ID: | 2120 |
| NCBI Accession: | P41212.1 |
| UniProt Secondary Accession: | P41212,Q9UMF6, Q9UMF7, Q9UMG0, A3QVP6, A8K076, |
| UniProt Related Accession: | P41212 |
| Molecular Weight: | 53,000 Da |
| NCBI Full Name: | Transcription factor ETV6 |
| NCBI Synonym Full Names: | ETS variant 6 |
| NCBI Official Symbol: | ETV6 |
| NCBI Official Synonym Symbols: | TEL; THC5; TEL/ABL |
| NCBI Protein Information: | transcription factor ETV6 |
| UniProt Protein Name: | Transcription factor ETV6 |
| UniProt Synonym Protein Names: | ETS translocation variant 6; ETS-related protein Tel1; Tel |
| Protein Family: | Transcription factor |
| UniProt Gene Name: | ETV6 |
| UniProt Entry Name: | ETV6_HUMAN |
