Description
Antibody Name: | ESX1 Antibody (PACO09149) |
Antibody SKU: | PACO09149 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | |
Species Reactivity: | Human, Mouse |
Immunogen: | Human ESX1 |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
Purification Method: | Antigen Affinity purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | ESX homeobox 1;ESX1;ESX1L;ESXR1 ; |
UniProt Protein Function: | ESX1L: May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase. ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5'-TAATGTTATTA-3' which is present within the first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover.Protein type: DNA-bindingChromosomal Location of Human Ortholog: Xq22.1Cellular Component: cytoplasm; nucleusMolecular Function: sequence-specific DNA bindingBiological Process: negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; regulation of cell cycle |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes a dual-function 65 kDa protein that undergoes proteolytic cleavage to produce a 45 kDa N-terminal fragment with a paired-like homeodomain and a 20 kDa C-terminal fragment with a proline-rich domain. The C-terminal fragment localizes to the cytoplasm while the N-terminal fragment localizes exclusively to the nucleus. In contrast to human, the mouse homolog has a novel PN/PF motif in the C-terminus and is paternally imprinted in placental tissue. This gene likely plays a role in placental development and spermatogenesis. [provided by RefSeq, Jan 2010] |
UniProt Code: | Q8N693 |
NCBI GenInfo Identifier: | 116241356 |
NCBI Gene ID: | 80712 |
NCBI Accession: | Q8N693.3 |
UniProt Secondary Accession: | Q8N693,Q7Z6K7, B0QYU3 |
UniProt Related Accession: | Q8N693 |
Molecular Weight: | 44,297 Da |
NCBI Full Name: | Homeobox protein ESX1 |
NCBI Synonym Full Names: | ESX homeobox 1 |
NCBI Official Symbol: | ESX1 |
NCBI Official Synonym Symbols: | ESX1L; ESXR1 |
NCBI Protein Information: | homeobox protein ESX1 |
UniProt Protein Name: | Homeobox protein ESX1 |
UniProt Synonym Protein Names: | Extraembryonic, spermatogenesis, homeobox 1 |
Protein Family: | Homeobox protein |
UniProt Gene Name: | ESX1 |
UniProt Entry Name: | ESX1_HUMAN |