ESR1 Monoclonal Antibody [LSERASC1] (CPAB0580)

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SKU:
CPAB0580
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Universal
Host Species:
Mouse
Isotype:
IgG
Clone:
LSERASC1
Applications:
WB
Applications:
IHC
Applications:
FC

Description

system_update_alt Datasheet
Product Name:ESR1 Antibody
Product Sku:CPAB0580
Size:500μg
Host Species:Mouse
Immunogen:Recombinant human ER-alpha.
Clone:LSERASC1.
Reactivity:Other bodies
Applications:Western Blot, Immunohistochemistry, Flow Cytometry
Purification Method:Protein A
Isotype:IgG
Background:Estrogen receptors ? (ER?, ER; NR3A1) is a member of the steroid hormone receptor family.  ER? is a ligand-activated transcription factor.  ER? contain DNA binding and ligand binding domains.   ER? is expressed in a wide variety of tissues, including ovary, uterus, breast, prostate, testis, epididymis, bones, bladder, kidney, heart, vessel wall, pituitary gland and hypothalamus. ER plays a variety of important roles in the maintenance of the reproductive, cardiovascular, musculoskeletal and central nervous systems.   The natural ligand for ER is 17?-estradiol, the classical estrogenic compound.  The binding of estrogen to ER induces a conformational change and triggers a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes.
Synonyms:ER-alpha
Storage Buffer:Lyophilized: store at 4°C. After reconstitution, if not intended for use within a month, aliquot and store at -20°C.
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