ERI1 Antibody (PACO06026)
- SKU:
- PACO06026
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | ERI1 Antibody (PACO06026) |
| Antibody SKU: | PACO06026 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:5000, WB:1:500-1:2000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from the Internal region of human ERI1. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | ERI1; 3'EXO; THEX1; 3'-5' exoribonuclease 1; 3'-5' exonuclease ERI1; Eri-1 homolog; Histone mRNA 3'-end-specific exoribonuclease; Histone mRNA 3'-exonuclease 1; Protein 3'hExo; HEXO |
| UniProt Protein Function: | THEX1: RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication- dependent histone pre-mRNAs. Identified in a histone pre-mRNA complex, at least composed of ERI1, LSM11, SLBP, SNRPB, SYNCRIP and YBX1. Interacts in a cooperative manner with SLBP to the mature 3'-end of histone mRNAs. Binds to 40S and 60S ribosomal subunits and to 80S assembled ribosomes. Found in a ternary complex with SLBP and the stem-loop structure of the 3'-end of histone mRNAs. Although it can bind simultaneously with SLBP to the 3'-end of histone mRNA, the presence of SLBP prevents the exonuclease activity.Protein type: EC 3.1.-.-; Hydrolase; NucleolusChromosomal Location of Human Ortholog: 8p23.1Cellular Component: cytoplasm; nucleolus; nucleusMolecular Function: 3'-5' exonuclease activity; ribosome binding; rRNA bindingBiological Process: exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); rRNA 3'-end processing |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q8IV48 |
| NCBI GenInfo Identifier: | 45476938 |
| NCBI Gene ID: | 90459 |
| NCBI Accession: | Q8IV48.3 |
| UniProt Secondary Accession: | Q8IV48,Q9NSX3, A8K4U7 |
| UniProt Related Accession: | Q8IV48 |
| Molecular Weight: | 40,064 Da |
| NCBI Full Name: | 3'-5' exoribonuclease 1 |
| NCBI Synonym Full Names: | exoribonuclease 1 |
| NCBI Official Symbol: | ERI1 |
| NCBI Official Synonym Symbols: | HEXO; THEX1; 3'HEXO |
| NCBI Protein Information: | 3'-5' exoribonuclease 1 |
| UniProt Protein Name: | 3'-5' exoribonuclease 1 |
| UniProt Synonym Protein Names: | 3'-5' exonuclease ERI1; Eri-1 homolog; Histone mRNA 3'-end-specific exoribonuclease; Histone mRNA 3'-exonuclease 1; Protein 3'hExo; HEXO |
| Protein Family: | ERI1 exoribonuclease |
| UniProt Gene Name: | ERI1 |
| UniProt Entry Name: | ERI1_HUMAN |
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