ERBB2 Monoclonal Antibody Polyclonal (CPAB0731)
- SKU:
- CPAB0731
Description
system_update_alt Datasheet
| Product Name: | ERBB2 Antibody Polyclonal |
| Product Sku: | CPAB0731 |
| Size: | 2μg |
| Host Species: | |
| Immunogen: | The erbb2 antibody was raised in rabbits by immunization with the recombinant Human erbb2 (43.4 kDa, 397 a.aand one extra AA, N-terminal Methionin) purified from Ecoli. |
| Clone: | |
| Reactivity: | Other Polyclonal bodies |
| Applications: |
| Purification Method: | |
| Isotype: | |
| Background: | HER-2/neu (erbB-2) encodes an 185-kDa orphan receptor tyrosine kinase that is constitutively active as a dimer and displays potent oncogenic activity when overexpressed. Herstatin, as the product of alternative HER-2 transcript, retains intron 8. The herstatin mRNA is expressed in normal human fetal kidney and liver, but is at reduced levels relative to p185HER-2 mRNA in carcinoma cells that contain an amplified HER-2 gene. Herstatin appears to be an inhibitor of p185HER-2, because it disrupts dimers, reduces tyrosine phosphorylation of p185, and inhibits the anchorage-independent growth of transformed cells that overexpress HER-2. |
| Synonyms: | NEU, NGL, HER2, TKR1, HER-2, c-erb B2, HER-2/neu, Receptor tyrosine-protein kinase erbB-2, EC 2.7.10.1, p185erbB2, C-erbB-2, NEU proto-oncogene, Tyrosine kinase-type cell surface receptor HER2, MLN 19, CD340 antigen. |
| Storage Buffer: |
Additional Information
Product Type: |
Antibody |
Antibody Type: |
Monoclonal Antibody |
Reactivity: |
Universal |
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