ERBB2 Monoclonal Antibody Polyclonal (CPAB0731)

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SKU:
CPAB0731
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Universal

Description

system_update_alt Datasheet
Product Name:ERBB2 Antibody Polyclonal
Product Sku:CPAB0731
Size:2μg
Host Species:
Immunogen:The erbb2 antibody was raised in rabbits by immunization with the recombinant Human erbb2 (43.4 kDa, 397 a.aand one extra AA, N-terminal Methionin) purified from Ecoli.
Clone:
Reactivity:Other Polyclonal bodies
Applications:
Purification Method:
Isotype:
Background:HER-2/neu (erbB-2) encodes an 185-kDa orphan receptor tyrosine kinase that is constitutively active as a dimer and displays potent oncogenic activity when overexpressed. Herstatin, as the product of alternative HER-2 transcript, retains intron 8. The herstatin mRNA is expressed in normal human fetal kidney and liver, but is at reduced levels relative to p185HER-2 mRNA in carcinoma cells that contain an amplified HER-2 gene. Herstatin appears to be an inhibitor of p185HER-2, because it disrupts dimers, reduces tyrosine phosphorylation of p185, and inhibits the anchorage-independent growth of transformed cells that overexpress HER-2.
Synonyms:NEU, NGL, HER2, TKR1, HER-2, c-erb B2, HER-2/neu, Receptor tyrosine-protein kinase erbB-2, EC 2.7.10.1, p185erbB2, C-erbB-2, NEU proto-oncogene, Tyrosine kinase-type cell surface receptor HER2, MLN 19, CD340 antigen.
Storage Buffer:
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