ERBB2 Monoclonal Antibody [P7H3BV] (CPAB0104)

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SKU:
CPAB0104
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Clone:
P7H3BV
Applications:
WB
Applications:
ELISA

Description

system_update_alt Datasheet
Product Name:ERBB2 Antibody
Product Sku:CPAB0104
Size:5μg
Host Species:
Immunogen:Anti-human ErbB2 mAb, is derived from mice immunized with the recombinant human ErbB2 (43.4 kDa, 397 a.aand one extra N-terminal Methionin) purified from Ecoli.
Clone:P7H3BV.
Reactivity:Human
Applications:Western Blot, ELISA
Purification Method:
Isotype:
Background:HER-2/neu (erbB-2) encodes an 185-kDa orphan receptor tyrosine kinase that is constitutively active as a dimer and displays potent oncogenic activity when overexpressed. Herstatin, as the product of alternative HER-2 transcript, retains intron 8. The herstatin mRNA is expressed in normal human fetal kidney and liver, but is at reduced levels relative to p185HER-2 mRNA in carcinoma cells that contain an amplified HER-2 gene. Herstatin appears to be an inhibitor of p185HER-2, because it disrupts dimers, reduces tyrosine phosphorylation of p185, and inhibits the anchorage-independent growth of transformed cells that overexpress HER-2.
Synonyms:NEU, NGL, HER2, TKR1, HER-2, c-erb B2, HER-2/neu, Receptor tyrosine-protein kinase erbB-2, EC 2.7.10.1, p185erbB2, C-erbB-2, NEU proto-oncogene, Tyrosine kinase-type cell surface receptor HER2, MLN 19, CD340 antigen.
Storage Buffer:
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