Enzymes Recombinant Proteins

ENO2 Protein Recombinant Protein (RPPB1702)

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SKU:
RPPB1702
Product Type:
Recombinant Protein
Uniprot:
P09104
Research Area:
Enzymes

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:ENO2 Protein Recombinant Protein
Product Code:RPPB1702
Size:100µg
Target:ENO2 Protein
Synonyms:Gamma-enolase, EC 4.2.1.11, 2-phospho-D-glycerate hydro-lyase, Neural enolase, Neuron-specific enolase, NSE, Enolase 2, ENO2.
Source:Human CNS
Physical Appearance:Sterile Filtered clear solution.
Formulation:The protein solution is in 0.01M NaH2PO4 buffer pH 7.4 containing 0.15M NaCl and 0.005M MgSO4.
Stability:Human NSE although stable at 4°C for 1 week, should be stored at -15°C.
Purity:Greater than 96.0%.

Neuron-specificenolase also caled NSE is a glycolytic isoenzyme which is situated in central and peripheral neurons and neuroendocrine cells. Enolase-2 is released into the CSF when neural tissue is injured. Neoplasms derived from neural or neuroendocrine tissue release Enolase-2 into the blood. Enolase-2 is a useful substance that has been detected in patients with certain tumors, such as neuroblastoma, small cell lung cancer, medullary thyroid cancer, carcinoid tumors, pancreatic endocrine tumors, and melanoma. ENO2 is 1 of the 3 enolase isoenzymes found in mammals. ENO2 isoenzyme, is found in mature neurons and cells of neuronal origin. An exchange from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates.

Human Neurone Specific Enolase produced in Human CNS having a molecular mass of 45kDa.

UniProt Protein Function:ENO2: an enzyme with 2-phospho-D-glycerate hydro-lyase activity. One of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates.
UniProt Protein Details:

Protein type:Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 4.2.1.11; Lyase

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: cytosol; extracellular space; myelin sheath; perikaryon; phosphopyruvate hydratase complex; photoreceptor inner segment; plasma membrane

Molecular Function:magnesium ion binding; phosphopyruvate hydratase activity; protein binding

Biological Process: carbohydrate metabolic process; gluconeogenesis; glucose metabolic process

NCBI Summary:This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates. [provided by RefSeq, Jul 2008]
UniProt Code:P09104
NCBI GenInfo Identifier:20981682
NCBI Gene ID:2026
NCBI Accession:P09104.3
UniProt Secondary Accession:P09104,Q96J33, B7Z2X9,
UniProt Related Accession:P09104
Molecular Weight:42,707 Da
NCBI Full Name:Gamma-enolase
NCBI Synonym Full Names:enolase 2 (gamma, neuronal)
NCBI Official Symbol:ENO2��
NCBI Official Synonym Symbols:NSE; HEL-S-279��
NCBI Protein Information:gamma-enolase
UniProt Protein Name:Gamma-enolase
UniProt Synonym Protein Names:2-phospho-D-glycerate hydro-lyase; Enolase 2; Neural enolase; Neuron-specific enolase; NSE
Protein Family:Gamma-enolase
UniProt Gene Name:ENO2��
UniProt Entry Name:ENOG_HUMAN
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system_update_altDatasheetHuman NSE/ENO2 Recombinant Protein Gamma-enolase; also known as Enolase 2; belongs to the enolase family. The alpha/alpha homodimer of ENO2 is expressed in embryo and in