EMX2 Antibody (PACO54754)
- SKU:
- PACO54754
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | EMX2 Antibody (PACO54754) |
| Antibody SKU: | PACO54754 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200 |
| Species Reactivity: | Human, Rat, Mouse |
| Immunogen: | Recombinant Human Homeobox protein EMX2 protein (75-141AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Rat brain tissue, Mouse brain tissue. All lanes: EMX2 antibody at 2.7µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 29, 19 kDa. Observed band size: 29 kDa. |
 | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO54754 at dilution of 1:100. |
| Background: | Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system. |
| Synonyms: | Homeobox protein EMX2 (Empty spiracles homolog 2) (Empty spiracles-like protein 2), EMX2 |
| UniProt Protein Function: | EMX2: Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system. Defects in EMX2 are the cause of schizencephaly (SCHZC). Schizencephaly is an extremely rare human congenital disorder characterized by a full-thickness cleft within the cerebral hemispheres. These clefts are lined with gray matter and most commonly involve the parasylvian regions. Large portions of the cerebral hemispheres may be absent and replaced by cerebro- spinal fluid. Belongs to the EMX homeobox family.Protein type: DNA-bindingChromosomal Location of Human Ortholog: 10q26.1Cellular Component: nucleusMolecular Function: protein binding; sequence-specific DNA bindingBiological Process: forebrain cell migration; neuron differentiation; response to drug; anterior/posterior pattern formation; dentate gyrus development; regulation of transcription, DNA-dependent; cell proliferation in forebrain; cerebral cortex regionalizationDisease: Schizencephaly |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a homeobox-containing transcription factor that is the homolog to the 'empty spiracles' gene in Drosophila. Research on this gene in humans has focused on its expression in three tissues: dorsal telencephalon, olfactory neuroepithelium, and urogenetial system. It is expressed in the dorsal telencephalon during development in a low rostral-lateral to high caudal-medial gradient and is proposed to pattern the neocortex into defined functional areas. It is also expressed in embryonic and adult olfactory neuroepithelia where it complexes with eukaryotic translation initiation factor 4E (eIF4E) and possibly regulates mRNA transport or translation. In the developing urogenital system, it is expressed in epithelial tissues and is negatively regulated by HOXA10. Alternative splicing results in multiple transcript variants encoding distinct proteins.[provided by RefSeq, Sep 2009] |
| UniProt Code: | Q04743 |
| NCBI GenInfo Identifier: | 19862512 |
| NCBI Gene ID: | 2018 |
| NCBI Accession: | Q04743.2 |
| UniProt Secondary Accession: | Q04743,Q96NN8, Q9BQF4, G3V305 |
| UniProt Related Accession: | Q04743 |
| Molecular Weight: | 18,518 Da |
| NCBI Full Name: | Homeobox protein EMX2 |
| NCBI Synonym Full Names: | empty spiracles homeobox 2 |
| NCBI Official Symbol: | EMX2 |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | homeobox protein EMX2; empty spiracles homolog 2; empty spiracles-like protein 2 |
| UniProt Protein Name: | Homeobox protein EMX2 |
| UniProt Synonym Protein Names: | Empty spiracles homolog 2; Empty spiracles-like protein 2 |
| Protein Family: | Homeobox protein |
| UniProt Gene Name: | EMX2 |
| UniProt Entry Name: | EMX2_HUMAN |
| Antibodies |
| EMX2 Antibody (PACO03620) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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