ELN Monoclonal Antibody (CAB22733)
- SKU:
- CAB22733
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
Description
| Product Name: | ELN Monoclonal Antibody |
| Product Code: | CAB22733 |
| Reactivity: | Human, Rat |
| Applications: | Western blotting, Immunohistochemistry, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC58665 |
| Reactivity: | Human, Rat |
| Tested Applications: | WB, IHC-P, IF/ICC, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry, Immunofluorescence |
| Recommended Dilution: | WB 1:500-1:1000, IHC-P 1:500-1:1000, IF/ICC 1:100-1:500 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | Rat heart |
| Cellular Location: | Secreted, extracellular matrix, extracellular space |
This gene encodes a protein that is one of the two components of elastic fibers. Elastic fibers comprise part of the extracellular matrix and confer elasticity to organs and tissues including the heart, skin, lungs, ligaments, and blood vessels. The encoded protein is rich in hydrophobic amino acids such as glycine and proline, which form mobile hydrophobic regions bounded by crosslinks between lysine residues. Degradation products of the encoded protein, known as elastin-derived peptides or elastokines, bind the elastin receptor complex and other receptors and stimulate migration and proliferation of monocytes and skin fibroblasts. Elastokines can also contribute to cancer progression. Deletions and mutations in this gene are associated with supravalvular aortic stenosis (SVAS) and autosomal dominant cutis laxa.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 27-200 of human ELN (NP_001265844.1). |
| Sequence: | GGVPG AIPGG VPGGV FYPGA GLGAL GGGAL GPGGK PLKPV PGGLA GAGLG AGLGA FPAVT FPGAL VPGGV ADAAA AYKAA KAGAG LGGVP GVGGL GVSAG AVVPQ PGAGV KPGKV PGVGL PGVYP GGVLP GARFP GVGVL PGVPT GAGVK PKAPG VGGAF AGIPG VGPFG GPQP |
| Synonyms: | WS, WBS, SVAS, ADCL1 |
| Calculated MW: | 68kDa |
| Observed MW: | 68kDa |
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