ELK3 Antibody (PACO55470)
- SKU:
- PACO55470
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | ELK3 Antibody (PACO55470) |
| Antibody SKU: | PACO55470 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:500-1:1000 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human ETS domain-containing protein Elk-3 protein (163-300AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO55470 diluted at 1:500 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
 | IHC image of PACO55470 diluted at 1:500 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element. |
| Synonyms: | ETS domain-containing protein Elk-3 (ETS-related protein ERP) (ETS-related protein NET) (Serum response factor accessory protein 2) (SAP-2) (SRF accessory protein 2), ELK3, NET SAP2 |
| UniProt Protein Function: | ELK3: a transcription factor of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. May be a negative regulator of transcription but can activate transcription when co expressed with Ras, Src or Mos. Activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present. |
| UniProt Protein Details: | Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 12q23 Cellular Component: intracellular membrane-bound organelle; mitochondrion; nucleoplasm; nucleus Molecular Function:protein binding; purine-rich negative regulatory element binding; transcription corepressor activity Biological Process: cell differentiation; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; signal transduction |
| NCBI Summary: | This gene encodes a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015] |
| UniProt Code: | P41970 |
| NCBI GenInfo Identifier: | 116241349 |
| NCBI Gene ID: | 2004 |
| NCBI Accession: | P41970.2 |
| UniProt Secondary Accession: | P41970,Q6FG57, Q6GU29, Q9UD17, B2R6S6, |
| UniProt Related Accession: | P41970,AAB34628 |
| Molecular Weight: | 44,240 Da |
| NCBI Full Name: | ETS domain-containing protein Elk-3 |
| NCBI Synonym Full Names: | ELK3, ETS transcription factor |
| NCBI Official Symbol: | ELK3 |
| NCBI Official Synonym Symbols: | ERP; NET; SAP2; SAP-2 |
| NCBI Protein Information: | ETS domain-containing protein Elk-3 |
| UniProt Protein Name: | ETS domain-containing protein Elk-3 |
| UniProt Synonym Protein Names: | ETS-related protein ERP; ETS-related protein NET; Serum response factor accessory protein 2; SAP-2; SRF accessory protein 2 |
| Protein Family: | ETS domain-containing protein |
| UniProt Gene Name: | ELK3 |
| UniProt Entry Name: | ELK3_HUMAN |
| Antibodies | ELISA Kits |
| Phospho-ELK3 (S357) Antibody (PACO02640) | Elk3 (Phospho-Ser357) Transcription Factor Activity Assay |
| ELK3 Antibody (PACO03611) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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