eIF4EBP1 Monoclonal Antibody
- SKU:
- CAB24691
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
Description
| Product Name: | eIF4EBP1 Monoclonal Antibody |
| Product Code: | CAB24691 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunohistochemistry, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC60753 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IHC-P, IF/ICC, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry, Immunofluorescence |
| Recommended Dilution: | WB 1:500-1:1000, IHC-P 1:50-1:200, IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | HeLa |
| Cellular Location: | Cytoplasm, Nuclear |
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 20-118 of human eIF4EBP1(NP_004086.1). |
| Sequence: | RVVLG DGVQL PPGDY STTPG GTLFS TTPGG TRIIY DRKFL MECRN SPVTK TPPRD LPTIP GVTSP SSDEP PMEAS QSHLR NSPED KRAGG EESQF EMDI |
| Synonyms: | BP-1, 4EBP1, 4E-BP1, PHAS-I |
| Calculated MW: | 13kDa |
| Observed MW: | 18-20kDa |
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