EID3 Antibody (PACO19589)
- SKU:
- PACO19589
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | EID3 Antibody (PACO19589) |
| Antibody SKU: | PACO19589 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:25-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human EID3 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19589(EID3 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO19589(EID3 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | EID3 is highly expressed in testis and shows homology to a region of EID1 implicated in binding to CBP/p300. EID3 acts as a potent inhibitor of nuclear receptor transcriptional activity by a mechanism that is independent of direct interactions with nuclear receptors, including SHP. Furthermore, EID3 directly binds to and blocks the SRC-1 interacting domain of CBP, which has been implicated to act as the interaction surface for nuclear receptor co-activators. Consistent with this idea, EID3 prevents recruitment of CBP to a natural nuclear receptor-regulated promoter. |
| Synonyms: | EP300 interacting inhibitor of differentiation 3 |
| UniProt Protein Function: | EID3: Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Belongs to the NSE4 family.Chromosomal Location of Human Ortholog: 12q23.3Cellular Component: chromosome, telomeric region; cytoplasm; nucleusMolecular Function: identical protein binding; protein bindingBiological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; DNA repair; DNA recombination |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q8N140 |
| NCBI GenInfo Identifier: | 56605998 |
| NCBI Gene ID: | 493861 |
| NCBI Accession: | NP_001008395.1 |
| UniProt Secondary Accession: | Q8N140 |
| UniProt Related Accession: | Q8N140 |
| Molecular Weight: | SDS-PAGE MW: 38kd |
| NCBI Full Name: | EP300-interacting inhibitor of differentiation 3 |
| NCBI Synonym Full Names: | EP300 interacting inhibitor of differentiation 3 |
| NCBI Official Symbol: | EID3 |
| NCBI Official Synonym Symbols: | NS4EB; NSE4B; NSMCE4B |
| NCBI Protein Information: | EP300-interacting inhibitor of differentiation 3 |
| UniProt Protein Name: | EP300-interacting inhibitor of differentiation 3 |
| UniProt Synonym Protein Names: | E1A-like inhibitor of differentiation 3; EID-1-like inhibitor of differentiation 3; Non-structural maintenance of chromosomes element 4 homolog B; NS4EB; Non-SMC element 4 homolog B |
| Protein Family: | EP300-interacting inhibitor of differentiation |
| UniProt Gene Name: | EID3 |
| UniProt Entry Name: | EID3_HUMAN |
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