EHD3 Antibody (PACO47114)
- SKU:
- PACO47114
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | EHD3 Antibody (PACO47114) |
| Antibody SKU: | PACO47114 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human EH domain-containing protein 3 protein (269-498AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human brain tissue using PACO47114 at dilution of 1:100. |
 | Immunofluorescent analysis of HepG2 cells using PACO47114 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO47114 at dilution of 1:100. |
| Background: | ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes tubulation of endocytic membranes. Binding to phosphatidic acid, induces its membrane tubulation activity (By similarity). Plays a role in endocytic transport. Involved in early endosome to recycling endosome compartment (ERC), retrograde early endosome to Golgi, and endosome to plasma membrane (rapid recycling) protein transport. Involved in the regulation of Golgi maintenance and morphology. Involved in the recycling of internalized D1 dopamine receptor. Plays a role in cardiac protein trafficking probably implicating ANK2. Involved in the ventricular membrane targeting of SLC8A1 and CACNA1C and probably the atrial membrane localization of CACNA1GG and CACNA1H implicated in the regulation of atrial myocyte exitability and cardiac conduction (By similarity). In conjunction with EHD4 may be involved in endocytic trafficking of KDR/VEGFR2 implicated in control of glomerular function (By similarity). Involved in the rapid recycling of integrin beta-3 implicated in cell adhesion maintenance. Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing (By similarity). Plays a role in the formation of the ciliary vesicle, an early step in cilium biogenesis; possibly sharing redundant functions with EHD1. |
| Synonyms: | EH domain-containing protein 3 (PAST homolog 3), EHD3, EHD2 PAST3 |
| UniProt Protein Function: | EHD3: Plays a role in endocytic transport.Chromosomal Location of Human Ortholog: 2p21Cellular Component: cytoplasm; endosome membrane; focal adhesion; nucleus; recycling endosome membraneMolecular Function: nucleic acid binding; protein bindingBiological Process: blood coagulation; cilium biogenesis; endocytic recycling; protein homooligomerization; receptor recycling |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9NZN3 |
| NCBI GenInfo Identifier: | 300669636 |
| NCBI Gene ID: | 30845 |
| NCBI Accession: | Q9NZN3.2 |
| UniProt Secondary Accession: | Q9NZN3,Q8N514, Q9NZB3, B4DFR5, D6W574 |
| UniProt Related Accession: | Q9NZN3 |
| Molecular Weight: | 19,584 Da |
| NCBI Full Name: | EH domain-containing protein 3 |
| NCBI Synonym Full Names: | EH domain containing 3 |
| NCBI Official Symbol: | EHD3 |
| NCBI Official Synonym Symbols: | PAST3 |
| NCBI Protein Information: | EH domain-containing protein 3 |
| UniProt Protein Name: | EH domain-containing protein 3 |
| UniProt Synonym Protein Names: | PAST homolog 3Curated |
| Protein Family: | EH domain-containing protein |
| UniProt Gene Name: | EHD3 |
| UniProt Entry Name: | EHD3_HUMAN |
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