| UniProt Protein Function: | EFNA2: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the EPHA2 receptor may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis. Belongs to the ephrin family.Protein type: Membrane protein, GPI anchor; Ligand, receptor tyrosine kinaseChromosomal Location of Human Ortholog: 19p13.3Cellular Component: extracellular region; plasma membrane; perikaryon; neuromuscular junctionMolecular Function: ephrin receptor bindingBiological Process: axon guidance; cell-cell signaling; olfactory bulb development; ephrin receptor signaling pathway; osteoclast differentiation; bone remodeling |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the ephrin family. The protein is composed of a signal sequence, a receptor-binding region, a spacer region, and a hydrophobic region. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. Posttranslational modifications determine whether this protein localizes to the nucleus or the cytoplasm. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O43921 |
| NCBI GenInfo Identifier: | 27894381 |
| NCBI Gene ID: | 1943 |
| NCBI Accession: | NP_001396.2 |
| UniProt Secondary Accession: | O43921 |
| UniProt Related Accession: | O43921 |
| Molecular Weight: | ~ 24kDa |
| NCBI Full Name: | ephrin-A2 |
| NCBI Synonym Full Names: | ephrin A2 |
| NCBI Official Symbol: | EFNA2 |
| NCBI Official Synonym Symbols: | ELF-1; EPLG6; LERK6; HEK7-L; LERK-6 |
| NCBI Protein Information: | ephrin-A2 |
| UniProt Protein Name: | Ephrin-A2 |
| UniProt Synonym Protein Names: | EPH-related receptor tyrosine kinase ligand 6; LERK-6; HEK7 ligand |
| Protein Family: | Ephrin |
| UniProt Gene Name: | EFNA2 |
| UniProt Entry Name: | EFNA2_HUMAN |
