Efna1 Antibody (PACO26397)
- SKU:
- PACO26397
- Product Type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | Efna1 Antibody (PACO26397) |
| Antibody SKU: | PACO26397 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Rat |
| Immunogen: | Recombinant Rat Ephrin-A1 protein (18-182AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis By similarity. |
| Synonyms: | Ephrin-A1 (EPH-related receptor tyrosine kinase ligand 1) (LERK-1) (Immediate early response protein B61) [Cleaved into: Ephrin-A1, secreted form], Efna1, Epgl1 Lerk1 |
| UniProt Protein Function: | Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis (). |
| UniProt Protein Details: | |
| NCBI Summary: | ligand of receptor tyrosine kinases; involved in thymic function and development [RGD, Feb 2006] |
| UniProt Code: | P97553 |
| NCBI GenInfo Identifier: | 61889105 |
| NCBI Gene ID: | 94268 |
| NCBI Accession: | NP_446051.2 |
| UniProt Secondary Accession: | P97553,Q6NS29 |
| UniProt Related Accession: | P97553 |
| Molecular Weight: | 21.4 kDa |
| NCBI Full Name: | ephrin-A1 |
| NCBI Synonym Full Names: | ephrin A1 |
| NCBI Official Symbol: | Efna1 |
| NCBI Official Synonym Symbols: | B61 |
| NCBI Protein Information: | ephrin-A1 |
| UniProt Protein Name: | Ephrin-A1 |
| UniProt Synonym Protein Names: | EPH-related receptor tyrosine kinase ligand 1; LERK-1 |
| Protein Family: | Ephrin |
| UniProt Gene Name: | Efna1 |
| UniProt Entry Name: | EFNA1_RAT |
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