EDNRA Antibody (PACO17819)
- SKU:
- PACO17819
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | EDNRA Antibody (PACO17819) |
| Antibody SKU: | PACO17819 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthetic peptide of human EDNRA |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO17819(EDNRA Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: MCF7 cells, Primary antibody: PACO17819(EDNRA Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO17819(EDNRA Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. |
| Synonyms: | endothelin receptor type A |
| UniProt Protein Function: | EDNRA: Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRA sub-subfamily. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 4q31.22 Cellular Component: nuclear membrane; integral to plasma membrane; T-tubule; plasma membrane; lipid raft Molecular Function:endothelin receptor activity; protein binding; phosphoinositide phospholipase C activity Biological Process: positive regulation of odontogenesis; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); neural crest cell development; metabolic process; heart development; smooth muscle cell proliferation; response to morphine; response to lipopolysaccharide; glucose transport; sensory perception of pain; signal transduction; enteric nervous system development; Rho protein signal transduction; regulation of epithelial cell proliferation; histamine secretion; elevation of cytosolic calcium ion concentration; negative regulation of cAMP biosynthetic process; smooth muscle contraction; fibroblast proliferation; regulation of blood pressure; protein kinase C activation; positive regulation of cell proliferation; artery smooth muscle contraction; aging; penile erection; vasoconstriction; in utero embryonic development; glomerular filtration; adenylate cyclase activation; respiratory gaseous exchange; patterning of blood vessels; cell proliferation; G-protein coupled receptor protein signaling pathway; phospholipase C activation; maternal process involved in parturition; response to hypoxia; positive regulation of protein amino acid phosphorylation; positive regulation of release of sequestered calcium ion into cytosol; negative regulation of apoptosis; positive regulation of inflammatory response Disease: Mandibulofacial Dysostosis With Alopecia; Migraine With Or Without Aura, Susceptibility To, 1 |
| NCBI Summary: | This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] |
| UniProt Code: | P25101 |
| NCBI GenInfo Identifier: | 119606 |
| NCBI Gene ID: | 1909 |
| NCBI Accession: | P25101.1 |
| UniProt Secondary Accession: | P25101,O43441, Q16432, Q16433, Q8TBH2, B2R723, B4E2V6 B7Z9G6, D3DP03, E7ER36, |
| UniProt Related Accession: | P25101,AAB24923 |
| Molecular Weight: | 23,803 Da |
| NCBI Full Name: | Endothelin-1 receptor |
| NCBI Synonym Full Names: | endothelin receptor type A |
| NCBI Official Symbol: | EDNRA |
| NCBI Official Synonym Symbols: | ETA; ET-A; ETAR; ETRA; ETA-R; hET-AR |
| NCBI Protein Information: | endothelin-1 receptor; G protein-coupled receptor; endothelin receptor subtype A; endothelin-1-specific receptor |
| UniProt Protein Name: | Endothelin-1 receptor |
| UniProt Synonym Protein Names: | Endothelin A receptor; ET-A; ETA-R; hET-AR |
| Protein Family: | Endothelin-1 receptor |
| UniProt Gene Name: | EDNRA |
| UniProt Entry Name: | EDNRA_HUMAN |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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