ECSCR Antibody (PACO53986)
- SKU:
- PACO53986
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | ECSCR Antibody (PACO53986) |
| Antibody SKU: | PACO53986 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Endothelial cell-specific chemotaxis regulator protein (25-124AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human lung tissue using PACO53986 at dilution of 1:100. |
 | Immunofluorescence staining of MCF-7 cells with PACO53986 at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunofluorescence staining of A549 cells with PACO53986 at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2. |
| Synonyms: | Endothelial cell-specific chemotaxis regulator (Apoptosis regulator through modulating IAP expression) (ARIA) (Endothelial cell-specific molecule 2), ECSCR, ECSM2 |
| UniProt Protein Function: | ECSM2: Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis via modulation of the actin cytoskeleton. Belongs to the ECSCR family.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 5q31.2Cellular Component: cytosol; plasma membraneBiological Process: negative regulation of angiogenesis |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is primarily found in endothelial cells and blood vessels, where it is involved in cell shape changes and EGF-induced cell migration. It can enhance the activation of vascular endothelial growth factor receptor-2/kinase insert domain receptor and also promote the proteolysis of internalized kinase insert domain receptor. This gene may play a role in angiogenesis-related diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014] |
| UniProt Code: | Q19T08 |
| NCBI GenInfo Identifier: | 121940639 |
| NCBI Gene ID: | 641700 |
| NCBI Accession: | Q19T08.1 |
| UniProt Secondary Accession: | Q19T08,B4E3H7, C3RSF2 |
| UniProt Related Accession: | Q19T08 |
| Molecular Weight: | 21,295 Da |
| NCBI Full Name: | Endothelial cell-specific chemotaxis regulator |
| NCBI Synonym Full Names: | endothelial cell surface expressed chemotaxis and apoptosis regulator |
| NCBI Official Symbol: | ECSCR |
| NCBI Official Synonym Symbols: | ARIA; ECSM2 |
| NCBI Protein Information: | endothelial cell-specific chemotaxis regulator |
| UniProt Protein Name: | Endothelial cell-specific chemotaxis regulator |
| UniProt Synonym Protein Names: | Apoptosis regulator through modulating IAP expression; ARIA; Endothelial cell-specific molecule 2 |
| Protein Family: | Endothelial cell-specific chemotaxis regulator |
| UniProt Gene Name: | ECSCR |
| UniProt Entry Name: | ECSCR_HUMAN |
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