Name: EBF2 Antibody (PACO47194)
SKU: PACO47194
Availability: OutOfStock

Antibody Name:	EBF2 Antibody (PACO47194)
Antibody SKU:	PACO47194
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:	Human
Immunogen:	Recombinant Human Transcription factor COE2 protein (53-254AA)

Form:	Liquid
Storage Buffer:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:	>95%, Protein G purified
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

Immunohistochemistry of paraffin-embedded human spleen tissue using PACO47194 at dilution of 1:100.

Background:	Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By similarity).
Synonyms:	Transcription factor COE2 (Early B-cell factor 2) (EBF-2), EBF2, COE2

UniProt Protein Function:	Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' ().
UniProt Protein Details:
NCBI Summary:	The protein encoded by this gene belongs to the COE (Collier/Olf/EBF) family of non-basic, helix-loop-helix transcription factors that have a well conserved DNA binding domain. The COE family proteins play an important role in variety of developmental processes. Studies in mouse suggest that this gene may be involved in the differentiation of osteoblasts. [provided by RefSeq, Oct 2011]
UniProt Code:	Q9HAK2
NCBI GenInfo Identifier:	113930703
NCBI Gene ID:	64641
NCBI Accession:	NP_073150
UniProt Secondary Accession:	Q9HAK2,Q66VZ3, Q6DK36, Q6IS86, Q6ISA4, A0PJM4, A6NMF7 F5H645
UniProt Related Accession:	Q9HAK2
Molecular Weight:	28,748 Da
NCBI Full Name:	transcription factor COE2
NCBI Synonym Full Names:	early B cell factor 2
NCBI Official Symbol:	EBF2
NCBI Official Synonym Symbols:	COE2; OE-3; EBF-2; O/E-3
NCBI Protein Information:	transcription factor COE2
UniProt Protein Name:	Transcription factor COE2
UniProt Synonym Protein Names:	Early B-cell factor 2; EBF-2
Protein Family:	EIN3-binding F-box protein
UniProt Gene Name:	EBF2
UniProt Entry Name: