Microbiology Recombinant Proteins
E.Coli UNG Recombinant Protein (RPPB2406)
- SKU:
- RPPB2406
- Product Type:
- Recombinant Protein
- Species:
- Escherichia coli
- Uniprot:
- P12295
- Research Area:
- Microbiology
Description
| Product Name: | E.Coli UNG Recombinant Protein |
| Product Code: | RPPB2406 |
| Size: | 10µg |
| Species: | E.Coli |
| Target: | UNG |
| Synonyms: | UDG, b2580, JW2564, EC 3.2.2.27, DGU, UNG15, HIGM5, Uracil-DNA Glycosylase 1, EC 3.2.2, HIGM4, UNG2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | UNG protein solution (0.5mg/ml) containing 20mM Tris-HClbuffer (pH8.0) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMANELTW HDVLAEEKQQ PYFLNTLQTV ASERQSGVTI YPPQKDVFNAFRFTELGDVK VVILGQDPYH GPGQAHGLAF SVRPGIAIPP SLLNMYKELE NTIPGFTRPN HGYLESWARQGVLLLNTVLT VRAGQAHSHA SLGWETFTDK VISLINQHRE GVVFLLWGSH AQKKGAIIDK QRHHVLKAPH PSPLSAHRGF FGCNHFVLANQWLEQRGETP IDWMPVLPAE SE |
| UniProt Code: | P12295 |
UNG is a member of the Uracil-DNA glycosylase family. One of his functions is to preventmutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond andinitiating the base-excision repair (BER) pathway. Uracil bases are formed as a result of cytosinedeamination or misincorporation of dUMP residues. After a mutation is formed,the mutagenic threatof uracil propagates through any subsequent DNA replication steps. Among the diseases associated with UNG are: congenital rubella,and immunodeficiency with hyper igm type 4.
UNG E.Coli Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 252 amino acids (1-229 a.a) and having a molecular mass of 28.1kDa.UNG is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
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