E-Cadherin Monoclonal Antibody (CAB22850)
- SKU:
- CAB22850
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
Description
| Product Name: | E-Cadherin Monoclonal Antibody |
| Product Code: | CAB22850 |
| Reactivity: | Human, Mouse |
| Applications: | Western blotting, Immunohistochemistry, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC57093 |
| Reactivity: | Human, Mouse |
| Tested Applications: | WB, IHC-P, IF/ICC, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry, Immunofluorescence |
| Recommended Dilution: | WB 1:500-1:1000, IHC-P 1:500-1:1000, IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | Mouse lung |
| Cellular Location: | Cell junction, Cell membrane, Endosome, Golgi apparatus, Single-pass type I membrane protein, trans-Golgi network |
This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16.
| Immunogen: | Recombinant funsion protein containing a sequence corresponding to amino acids 155-707 of human E-Cadherin (NP_004351.1). |
| Sequence: | DWVIP PISCP ENEKG PFPKN LVQIK SNKDK EGKVF YSITG QGADT PPVGV FIIER ETGWL KVTEP LDRER IATYT LFSHA VSSNG NAVED PMEIL ITVTD QNDNK PEFTQ EVFKG SVMEG ALPGT SVMEV TATDA DDDVN TYNAA IAYTI LSQDP ELPDK NMFTI NRNTG VISVV TTGLD RESFP TYTLV VQAAD LQGEG LSTTA TAVIT VTDTN DNPPI FNPTT YKGQV PENEA NVVIT TLKVT DADAP NTPAW EAVYT ILNDD GGQFV VTTNP VNNDG ILKTA KGLDF EAKQQ YILHV AVTNV VPFEV SLTTS TATVT VDVLD VNEAP IFVPP EKRVE VSEDF GVGQE ITSYT AQEPD TFMEQ KITYR IWRDT ANWLE INPDT GAIST RAELD REDFE HVKNS TYTAL IIATD NGSPV ATGTG TLLLI LSDVN DNAPI PEPRT IFFCE RNPKP QVINI IDADL PPNTS PFTAE LTHGA SANWT IQYND PTQES IILKP KMALE VGDYK INLKL MDNQN KDQVT TLEVS VCDCE GAAGV CRKAQ PVEAG LQI |
| Synonyms: | UVO, CDHE, ECAD, LCAM, Arc-1, BCDS1, CD324 |
| Calculated MW: | 97kDa |
| Observed MW: | 135kDa |
Related Products
E-Cadherin Rabbit Monoclonal Antibody
E-Cadherin Monoclonal Antibody (CAB22333)
