DYRK1B Antibody (PACO21994)
- SKU:
- PACO21994
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | DYRK1B Antibody (PACO21994) |
| Antibody SKU: | PACO21994 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthesized peptide derived from internal of human DYR1B. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from Jurkat cells, using DYR1B antibody. |
| Background: | Dual-specificity kinase which possesses both serine/ threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Grimwood J., Nature 428:529-535(2004). |
| Synonyms: | DYR1B; Dual-specificity tyrosine-phosphorylation regulated kinase 1B; EC 2.7.12.1; MIRK; Mirk protein kinase |
| UniProt Protein Function: | DYRK1B: a dual-specificity protein kinase of the DYRK family. Localizes in the nucleus, where it enhances the transcriptional activity of TCF1/HNF1A. A co-activator of FKHR (FOXO1a)-dependent glucose-6-phosphatase gene expression. Induced by members of the Rho-family in myoblasts. Highest expression in skeletal muscle, testis, heart and brain with little expression in colon or lung. Expressed in a variety of tumor cell lines. Contains a bipartite nuclear targeting signal sequence. Three splice-variant isoforms have been described.Protein type: Kinase, protein; EC 2.7.12.1; Protein kinase, dual-specificity (non-receptor); Protein kinase, CMGC; CMGC group; DYRK family; Dyrk1 subfamilyChromosomal Location of Human Ortholog: 19q13.2Molecular Function: protein binding; protein kinase activity; transcription coactivator activityBiological Process: positive regulation of transcription, DNA-dependent; protein amino acid phosphorylationDisease: Abdominal Obesity-metabolic Syndrome 3 |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of a family of nuclear-localized protein kinases. The encoded protein participates in the regulation of the cell cycle. Expression of this gene may be altered in tumor cells, and mutations in this gene were found to cause abdominal obesity-metabolic syndrome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014] |
| UniProt Code: | Q9Y463 |
| NCBI GenInfo Identifier: | 9296963 |
| NCBI Gene ID: | 9149 |
| NCBI Accession: | Q9Y463.1 |
| UniProt Secondary Accession: | Q9Y463,O75258, O75788, O75789 |
| UniProt Related Accession: | Q9Y463 |
| Molecular Weight: | 66,336 Da |
| NCBI Full Name: | Dual specificity tyrosine-phosphorylation-regulated kinase 1B |
| NCBI Synonym Full Names: | dual specificity tyrosine phosphorylation regulated kinase 1B |
| NCBI Official Symbol: | DYRK1B |
| NCBI Official Synonym Symbols: | MIRK; AOMS3 |
| NCBI Protein Information: | dual specificity tyrosine-phosphorylation-regulated kinase 1B |
| UniProt Protein Name: | Dual specificity tyrosine-phosphorylation-regulated kinase 1B |
| UniProt Synonym Protein Names: | Minibrain-related kinase; Mirk protein kinase |
| Protein Family: | Dual specificity tyrosine-phosphorylation-regulated kinase |
| UniProt Gene Name: | DYRK1B |
| UniProt Entry Name: | DYR1B_HUMAN |
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