Description
Antibody Name: | DYNC1LI1 Antibody (PACO62651) |
Antibody SKU: | PACO62651 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:200-1:500 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Cytoplasmic dynein 1 light intermediate chain 1 protein (167-233AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
IHC image of PACO62651 diluted at 1:200 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
Background: | Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores. |
Synonyms: | Cytoplasmic dynein 1 light intermediate chain 1 (LIC1) (Dynein light chain A) (DLC-A) (Dynein light intermediate chain 1, cytosolic), DYNC1LI1, DNCLI1 |
UniProt Protein Function: | |
UniProt Protein Details: | |
NCBI Summary: | The protein encoded by this gene belongs to light intermediate subunit family, whose members are components of the multiprotein cytoplasmic dynein complex, which is involved in intracellular trafficking and chromosome segregation during mitosis. The protein plays a role in moving the spindle assembly checkpoint (SAC) from kinetochores to spindle poles. The protein may also mediate binding to other cargo molecules to facilitate intracellular vesicle trafficking. [provided by RefSeq, Jul 2016] |
UniProt Code: | Q9Y6G9 |
NCBI GenInfo Identifier: | 166795297 |
NCBI Gene ID: | 51143 |
NCBI Accession: | NP_057225 |
UniProt Secondary Accession: | Q9Y6G9 |
UniProt Related Accession: | Q9Y6G9 |
Molecular Weight: | |
NCBI Full Name: | cytoplasmic dynein 1 light intermediate chain 1 isoform 1 |
NCBI Synonym Full Names: | dynein cytoplasmic 1 light intermediate chain 1 |
NCBI Official Symbol: | DYNC1LI1 |
NCBI Official Synonym Symbols: | LIC1; DLC-A; DNCLI1 |
NCBI Protein Information: | cytoplasmic dynein 1 light intermediate chain 1 |
UniProt Protein Name: | Cytoplasmic dynein 1 light intermediate chain 1 |
UniProt Synonym Protein Names: | Dynein light chain A; DLC-A; Dynein light intermediate chain 1, cytosolic |
Protein Family: | |
UniProt Gene Name: | DYNC1LI1 |
UniProt Entry Name: | DC1L1_HUMAN |