DXO Antibody (PACO49534)
- SKU:
- PACO49534
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | DXO Antibody (PACO49534) |
| Antibody SKU: | PACO49534 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Decapping and exoribonuclease protein (69-266AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human testis tissue using PACO49534 at dilution of 1:100. |
 | Immunofluorescent analysis of Hela cells using PACO49534 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping, pyrophosphohydrolase and 5'-3' exonuclease activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. The 5' end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates (By similarity). |
| Synonyms: | Decapping and exoribonuclease protein (DXO) (EC 3.1.13) (EC 3.6.1) (Dom-3 homolog Z), DXO, DOM3L DOM3Z NG6 |
| UniProt Protein Function: | DOM3Z: May possess pyrophosphohydrolase activity towards 5' triphosphorylated RNA. Belongs to the Dom3Z family.Protein type: Unknown functionChromosomal Location of Human Ortholog: 6p21.3Cellular Component: cytoplasm; nucleus; plasma membraneMolecular Function: 5'-3' exonuclease activity; magnesium ion binding; mRNA bindingBiological Process: metabolic process; mRNA catabolic process; RNA destabilization |
| UniProt Protein Details: | |
| NCBI Summary: | This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. The function of its protein product is unknown, but its ubiquitous expression and conservation in both simple and complex eukaryotes suggests that this may be a housekeeping gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O77932 |
| NCBI GenInfo Identifier: | 115311709 |
| NCBI Gene ID: | 1797 |
| NCBI Accession: | O77932.2 |
| UniProt Secondary Accession: | O77932,O15004, O78127, O78128, Q5ST60, Q6IPZ2, Q9NPK4 A2CER3, B0UZ80 |
| UniProt Related Accession: | O77932 |
| Molecular Weight: | 44,929 Da |
| NCBI Full Name: | Decapping and exoribonuclease protein |
| NCBI Synonym Full Names: | decapping exoribonuclease |
| NCBI Official Symbol: | DXO |
| NCBI Official Synonym Symbols: | NG6; RAI1; DOM3L; DOM3Z |
| NCBI Protein Information: | decapping and exoribonuclease protein |
| UniProt Protein Name: | Decapping and exoribonuclease protein |
| UniProt Synonym Protein Names: | Dom-3 homolog Z |
| Protein Family: | Decapping and exoribonuclease protein |
| UniProt Gene Name: | DXO |
| UniProt Entry Name: | DXO_HUMAN |
| Antibodies |
| DXO Antibody (PACO08918) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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