DVL1 Polyclonal Antibody
- SKU:
- CAB24657
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | DVL1 Polyclonal Antibody |
| Product Code: | CAB24657 |
| Reactivity: | Mouse |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Mouse |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:2000-1:5000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Positive Samples: | Mouse brain |
| Cellular Location: | Cell membrane, Cytoplasm, Cytoplasmic side, Cytoplasmic vesicle, Peripheral membrane protein, cytosol |
DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 11-110 of human DVL1 (NP_001317240.1). |
| Sequence: | DEEET PYLVK LPVAP ERVTL ADFKN VLSNR PVHAY KFFFK SMDQD FGVVK EEIFD DNAKL PCFNG RVVSW LVLAE GAHSD AGSQG TDSHT DLPPP LERTG |
| Synonyms: | DVL, DRS2, DVL1L1, DVL1P1 |
| Calculated MW: | 75kDa |
| Observed MW: | 85kDa |
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