DUSP7 Antibody (PACO43728)
- SKU:
- PACO43728
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | DUSP7 Antibody (PACO43728) |
| Antibody SKU: | PACO43728 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Dual specificity protein phosphatase 7 protein (160-419AA) |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: Dual specificity protein phosphatase 7 antibody at 10µg/ml + HepG2 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 45, 41 kDa Observed band size: 45 kDa |
 | Immunohistochemistry of paraffin-embedded human breast cancer using PACO43728 at dilution of 1:100 |
 | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO43728 at dilution of 1:100 |
| Background: | Regulates the activity of the MAP kinase family in response to changes in the cellular environment. PYST2-S may act as a negative regulator of PYST2-L although it is unclear whether this is by competing for transcription, translation or activation factors. |
| Synonyms: | Dual specificity protein phosphatase 7 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase PYST2), DUSP7, PYST2 |
| UniProt Protein Function: | |
| UniProt Protein Details: | |
| NCBI Summary: | Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. DUSP7 belongs to a class of DUSPs, designated MKPs, that dephosphorylate MAPK (mitogen-activated protein kinase) proteins ERK (see MIM 601795), JNK (see MIM 601158), and p38 (see MIM 600289) with specificity distinct from that of individual MKP proteins. MKPs contain a highly conserved C-terminal catalytic domain and an N-terminal Cdc25 (see MIM 116947)-like (CH2) domain. MAPK activation cascades mediate various physiologic processes, including cellular proliferation, apoptosis, differentiation, and stress responses (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009] |
| UniProt Code: | Q16829 |
| NCBI GenInfo Identifier: | 238231453 |
| NCBI Gene ID: | 1849 |
| NCBI Accession: | NP_001938.2 |
| UniProt Secondary Accession: | Q16829 |
| UniProt Related Accession: | Q16829 |
| Molecular Weight: | |
| NCBI Full Name: | dual specificity protein phosphatase 7 |
| NCBI Synonym Full Names: | dual specificity phosphatase 7 |
| NCBI Official Symbol: | DUSP7 |
| NCBI Official Synonym Symbols: | MKPX; PYST2 |
| NCBI Protein Information: | dual specificity protein phosphatase 7 |
| UniProt Protein Name: | Dual specificity protein phosphatase 7 |
| UniProt Synonym Protein Names: | Dual specificity protein phosphatase PYST2 |
| Protein Family: | Dual specificity protein phosphatase |
| UniProt Gene Name: | DUSP7 |
| UniProt Entry Name: | DUS7_HUMAN |
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