DUSP16 Antibody (PACO23280)
- SKU:
- PACO23280
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | DUSP16 Antibody (PACO23280) |
| Antibody SKU: | PACO23280 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000, IF:1:100-1:500 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthesized peptide derived from internal of human DUSP16. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from Jurkat cells and COLO205 cells, using DUSP16 antibody. |
 | Immunofluorescence analysis of HepG2 cells, using DUSP16 antibody. |
| Background: | This gene encodes a mitogen-activated protein kinase phosphatase that is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. The encoded protein specifically regulates the c-Jun amino-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) pathways. |
| Synonyms: | Dual specificity protein phosphatase 16; EC 3.1.3.48; EC 3.1.3.16; Mitogen-activated protein kinase phosphatase 7; MAP kinase phosphatase 7 |
| UniProt Protein Function: | NPM1 iso3: a nucleolar protein associated with nucleolar ribonucleoprotein structures and that binds single-stranded nucleic acids. Is a major component of template activating factor (TAF)-III. It plays a role in controlling centrosome duplication, and may function in the assembly and/or transport of the ribosome. Two alternatively spliced isoforms have been described.Protein type: Oncoprotein; Translation; Nucleolus; RNA-bindingChromosomal Location of Human Ortholog: 5q35.1Cellular Component: nucleoplasm; centrosome; focal adhesion; membrane; cytoplasm; nucleolus; spindle pole centrosome; nucleus; ribonucleoprotein complex; cytosolMolecular Function: protein homodimerization activity; protein kinase inhibitor activity; histone binding; RNA binding; unfolded protein binding; transcription coactivator activity; protein kinase binding; ribosomal large subunit binding; NF-kappaB binding; protein binding; Tat protein binding; protein heterodimerization activity; ribosomal small subunit bindingBiological Process: regulation of centriole replication; viral reproduction; positive regulation of translation; centrosome cycle; cell aging; nucleocytoplasmic transport; signal transduction; DNA repair; protein oligomerization; activation of NF-kappaB transcription factor; intracellular protein transport; nucleosome assembly; negative regulation of cell proliferation; protein localization; regulation of endodeoxyribonuclease activity; DNA replication-independent nucleosome assembly at centromere; ribosome assembly; response to stress; negative regulation of apoptosis |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is involved in several cellular processes, including centrosome duplication, protein chaperoning, and cell proliferation. The encoded phosphoprotein shuttles between the nucleolus, nucleus, and cytoplasm, chaperoning ribosomal proteins and core histones from the nucleus to the cytoplasm. This protein is also known to sequester the tumor suppressor ARF in the nucleolus, protecting it from degradation until it is needed. Mutations in this gene are associated with acute myeloid leukemia. Dozens of pseudogenes of this gene have been identified. [provided by RefSeq, Aug 2017] |
| UniProt Code: | Q9BYG9 |
| NCBI GenInfo Identifier: | 83641870 |
| NCBI Gene ID: | 4869 |
| NCBI Accession: | NP_001032827.1 |
| UniProt Secondary Accession: | Q9BYG9 |
| UniProt Related Accession: | Q9BYG9,P06748 |
| Molecular Weight: | ~ 36kDa |
| NCBI Full Name: | nucleophosmin isoform 3 |
| NCBI Synonym Full Names: | nucleophosmin 1 |
| NCBI Official Symbol: | NPM1 |
| NCBI Official Synonym Symbols: | B23; NPM |
| NCBI Protein Information: | nucleophosmin |
| UniProt Protein Name: | Nucleophosmin |
| UniProt Synonym Protein Names: | Nucleolar phosphoprotein B23; Nucleolar protein NO38; Numatrin |
| Protein Family: | Nucleophosmin |
| UniProt Gene Name: | NPM1 |
| UniProt Entry Name: | NPM_HUMAN |
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