DUSP1/MKP1 Monoclonal Antibody
- SKU:
- CAB22201
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | DUSP1/MKP1 Monoclonal Antibody |
| Product Code: | CAB22201 |
| Reactivity: | Human |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC56245 |
| Reactivity: | Human |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:1000-1:5000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | HepG2 |
| Cellular Location: | Nucleus |
The protein encoded by this gene is a phosphatase with dual specificity for tyrosine and threonine. The encoded protein can dephosphorylate MAP kinase MAPK1/ERK2, which results in its involvement in several cellular processes. This protein appears to play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. Finally, the encoded protein can make some solid tumors resistant to both chemotherapy and radiotherapy, making it a target for cancer therapy.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human DUSP1/MKP1 (NP_004408.1). |
| Sequence: | GTLAL AAGAL CREAR AAQVF FLKGG YEAFS ASCPE LCSKQ STPMG LSLPL STSVP DSAES GCSSC STPLY DQGGP VEILP FLYLG SAYHA SRKDM LDALG I |
| Synonyms: | HVH1, MKP1, CL100, MKP-1, PTPN10 |
| Calculated MW: | 39kDa |
| Observed MW: | 39kDa |
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