DUS2 Antibody (PACO23287)
- SKU:
- PACO23287
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | DUS2 Antibody (PACO23287) |
| Antibody SKU: | PACO23287 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000, IHC:1:50-1:100 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthesized peptide derived from C-terminal of human DUS2L. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from RAW264.7 cells, using DUS2L antibody. |
 | Immunohistochemistry analysis of paraffin-embedded human skeletal muscle using DUS2L antibody. |
| Background: | Dihydrouridine synthase. Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR. |
| Synonyms: | tRNA-dihydrouridine synthase 2-like; EC 1.-.-.-; hDUS2; Up-regulated in lung cancer; URLC8 |
| UniProt Protein Function: | DUS2L: Dihydrouridine synthase. Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Belongs to the dus family. Dus2 subfamily.Protein type: EC 1.3.1.-; EC 1.-.-.-; RNA-binding; OxidoreductaseChromosomal Location of Human Ortholog: 16q22.1Cellular Component: cytoplasm; cytosolMolecular Function: double-stranded RNA binding; protein binding; protein kinase inhibitor activity; tRNA dihydrouridine synthase activity |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a cytoplasmic protein that catalyzes the conversion of uridine residues to dihydrouridine in the D-loop of tRNA. The resulting modified bases confer enhanced regional flexibility to tRNA. The encoded protein may increase the rate of translation by inhibiting an interferon-induced protein kinase. This gene has been implicated in pulmonary carcinogenesis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012] |
| UniProt Code: | Q9NX74 |
| NCBI GenInfo Identifier: | 73620832 |
| NCBI Gene ID: | 54920 |
| NCBI Accession: | Q9NX74.1 |
| UniProt Secondary Accession: | Q9NX74,Q4H4D9, A8K3G3 |
| UniProt Related Accession: | Q9NX74 |
| Molecular Weight: | 55,050 Da |
| NCBI Full Name: | tRNA-dihydrouridine(20) synthase |
| NCBI Synonym Full Names: | dihydrouridine synthase 2 |
| NCBI Official Symbol: | DUS2 |
| NCBI Official Synonym Symbols: | SMM1; DUS2L; URLC8 |
| NCBI Protein Information: | tRNA-dihydrouridine(20) synthase [NAD(P)+]-like |
| UniProt Protein Name: | tRNA-dihydrouridine(20) synthase [NAD(P)+]-like |
| UniProt Synonym Protein Names: | Dihydrouridine synthase 2; Up-regulated in lung cancer protein 8; URLC8; tRNA-dihydrouridine synthase 2-like; hDUS2 |
| Protein Family: | Probable tRNA-dihydrouridine synthase |
| UniProt Gene Name: | DUS2 |
| UniProt Entry Name: | DUS2L_HUMAN |
| Antibodies |
| DUS2 Antibody (PACO04663) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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