Description
Antibody Name: | DUOXA1 Antibody (PACO50114) |
Antibody SKU: | PACO50114 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Dual oxidase maturation factor 1 protein (73-183AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunofluorescent analysis of Hela cells using PACO50114 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | May be required for the maturation and the transport from the endoplasmic reticulum to the plasma membrane of functional DUOX1. |
Synonyms: | Dual oxidase maturation factor 1 (Dual oxidase activator 1) (Numb-interacting protein), DUOXA1, NIP NUMBIP |
UniProt Protein Function: | DUOXA1: May be required for the maturation and the transport from the endoplasmic reticulum to the plasma membrane of functional DUOX1 (Probable). Belongs to the DUOXA family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 15q21.1Cellular Component: membrane |
UniProt Protein Details: | |
NCBI Summary: | Dual oxidases DUOX1 and DUOX2 are NADPH oxidases which are involved in hydrogen peroxide production necessary for thyroid hormonogenesis. They form a heterodimer with specific maturation factors DUOXA1 and DUOXA2, respectively, which is essential for the maturation and function of the DUOX enzyme complexes. This gene encodes the DUOX1 activator or maturation factor DUOXA1. Rat studies identified a bidirectional promoter which controls the transcription of the DUOX1 and DUOXA1 genes. This protein is cotransported to the cell surface when coexpressed with DUOX1 and is retained in the endoplasmic reticulum when expressed without DUOX1 protein. The expression of this gene or the DUOX1 gene is not suppressed by thyroglobulin (Tg), a macromolecular precursor in thyroid hormone synthesis, while the expression of the DUOX2 and DUOXA2 are significantly suppressed by the Tg. This protein is also a p53-regulated neurogenic factor involved in p53 dependent neuronal differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013] |
UniProt Code: | Q1HG43 |
NCBI GenInfo Identifier: | 20987583 |
NCBI Gene ID: | 90527 |
NCBI Accession: | BC029819 |
UniProt Secondary Accession: | Q1HG43,Q8N6K9, Q96MI4 |
UniProt Related Accession: | Q1HG43 |
Molecular Weight: | 33,111 Da |
NCBI Full Name: | Homo sapiens dual oxidase maturation factor 1, mRNA |
NCBI Synonym Full Names: | dual oxidase maturation factor 1 |
NCBI Official Symbol: | DUOXA1 |
NCBI Official Synonym Symbols: | NIP; mol; NUMBIP |
NCBI Protein Information: | dual oxidase maturation factor 1 |
UniProt Protein Name: | Dual oxidase maturation factor 1 |
UniProt Synonym Protein Names: | Dual oxidase activator 1; Numb-interacting protein |
Protein Family: | |
UniProt Gene Name: | DUOXA1 |
UniProt Entry Name: | DOXA1_HUMAN |