DTX4 Antibody (PACO46710)
- SKU:
- PACO46710
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | DTX4 Antibody (PACO46710) |
| Antibody SKU: | PACO46710 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human E3 ubiquitin-protein ligase DTX4 protein (167-432AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunofluorescent analysis of HepG2 cells using PACO46710 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations (By similarity). Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4. |
| Synonyms: | E3 ubiquitin-protein ligase DTX4 (EC 2.3.2.27) (Protein deltex-4) (Deltex4) (RING finger protein 155) (RING-type E3 ubiquitin transferase DTX4), DTX4, KIAA0937 RNF155 |
| UniProt Protein Function: | DTX4: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Functions as an ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4. Belongs to the Deltex family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 6.3.2.-; Ubiquitin conjugating systemChromosomal Location of Human Ortholog: 11q12.1Cellular Component: cytosolMolecular Function: zinc ion binding; ligase activityBiological Process: regulation of interferon type I production; Notch signaling pathway; positive regulation of interferon type I production; protein ubiquitination; innate immune response |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9Y2E6 |
| NCBI GenInfo Identifier: | 148237498 |
| NCBI Gene ID: | 23220 |
| NCBI Accession: | NP_055992.1 |
| UniProt Secondary Accession: | Q9Y2E6,Q0VF38 |
| UniProt Related Accession: | Q9Y2E6 |
| Molecular Weight: | 67,258 Da |
| NCBI Full Name: | E3 ubiquitin-protein ligase DTX4 isoform 1 |
| NCBI Synonym Full Names: | deltex 4, E3 ubiquitin ligase |
| NCBI Official Symbol: | DTX4 |
| NCBI Official Synonym Symbols: | RNF155 |
| NCBI Protein Information: | E3 ubiquitin-protein ligase DTX4; deltex4; deltex 4 homolog; deltex homolog 4; protein deltex-4; RING finger protein 155 |
| UniProt Protein Name: | E3 ubiquitin-protein ligase DTX4 |
| UniProt Synonym Protein Names: | Protein deltex-4; Deltex4; RING finger protein 155 |
| Protein Family: | Protein DETOXIFICATION |
| UniProt Gene Name: | DTX4 |
| UniProt Entry Name: | DTX4_HUMAN |
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