DTX3 Antibody (PACO14338)
- SKU:
- PACO14338
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | DTX3 Antibody (PACO14338) |
| Antibody SKU: | PACO14338 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Fusion protein of human DTX3 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human lymphoma tissue, Primary antibody: PACO14338(DTX3 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 minutes. |
| Background: | DTX3 functions as an E3 ubiquitin ligase. Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context By similarity. Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. |
| Synonyms: | Deltex homolog 3 (Drosophila) |
| UniProt Protein Function: | DTX3: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. Belongs to the Deltex family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Ubiquitin ligase; Ligase; Ubiquitin conjugating system; EC 6.3.2.-Chromosomal Location of Human Ortholog: 12q13.3Molecular Function: protein binding |
| UniProt Protein Details: | |
| NCBI Summary: | DTX3 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009] |
| UniProt Code: | Q8N9I9 |
| NCBI GenInfo Identifier: | 37077338 |
| NCBI Gene ID: | 196403 |
| NCBI Accession: | Q8N9I9.2 |
| UniProt Secondary Accession: | Q8N9I9,Q53ZZ2, Q8NAU6, Q8NDS8 |
| UniProt Related Accession: | Q8N9I9 |
| Molecular Weight: | 38,155 Da |
| NCBI Full Name: | Probable E3 ubiquitin-protein ligase DTX3 |
| NCBI Synonym Full Names: | deltex E3 ubiquitin ligase 3 |
| NCBI Official Symbol: | DTX3 |
| NCBI Official Synonym Symbols: | RNF154; deltex3 |
| NCBI Protein Information: | probable E3 ubiquitin-protein ligase DTX3 |
| UniProt Protein Name: | Probable E3 ubiquitin-protein ligase DTX3 |
| UniProt Synonym Protein Names: | Protein deltex-3; Deltex3; RING finger protein 154 |
| Protein Family: | Protein DETOXIFICATION |
| UniProt Gene Name: | DTX3 |
| UniProt Entry Name: | DTX3_HUMAN |
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