DSCC1 Antibody (PACO42110)
- SKU:
- PACO42110
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | DSCC1 Antibody (PACO42110) |
| Antibody SKU: | PACO42110 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Sister chromatid cohesion protein DCC1 protein (1-393AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: DSCC1 antibody at 8µg/ml + CEM whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 45 kDa. Observed band size: 45 kDa. |
| Background: | Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3. |
| Synonyms: | Sister chromatid cohesion protein DCC1 (Defective in sister chromatid cohesion protein 1 homolog), DSCC1, DCC1 |
| UniProt Protein Function: | DCC1: Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3. Belongs to the DCC1 family.Chromosomal Location of Human Ortholog: 8q24.12Cellular Component: chromatin; chromosome, pericentric region; nucleoplasmMolecular Function: DNA clamp loader activity; protein binding; single-stranded DNA-dependent ATPase activityBiological Process: maintenance of mitotic sister chromatid cohesion; regulation of DNA replication |
| UniProt Protein Details: | |
| NCBI Summary: | CHTF18 (MIM 613201), CHTF8 (MIM 613202), and DSCC1 are components of an alternative replication factor C (RFC) (see MIM 600404) complex that loads PCNA (MIM 176740) onto DNA during S phase of the cell cycle (Merkle et al., 2003 [PubMed 12766176]; Bermudez et al., 2003 [PubMed 12930902]).[supplied by OMIM, Dec 2009] |
| UniProt Code: | Q9BVC3 |
| NCBI GenInfo Identifier: | 167012058 |
| NCBI Gene ID: | 79075 |
| NCBI Accession: | Q9BVC3.2 |
| UniProt Secondary Accession: | Q9BVC3,Q969N5 |
| UniProt Related Accession: | Q9BVC3 |
| Molecular Weight: | 44,825 Da |
| NCBI Full Name: | Sister chromatid cohesion protein DCC1 |
| NCBI Synonym Full Names: | DNA replication and sister chromatid cohesion 1 |
| NCBI Official Symbol: | DSCC1 |
| NCBI Official Synonym Symbols: | DCC1 |
| NCBI Protein Information: | sister chromatid cohesion protein DCC1 |
| UniProt Protein Name: | Sister chromatid cohesion protein DCC1 |
| UniProt Synonym Protein Names: | Defective in sister chromatid cohesion protein 1 homolog |
| Protein Family: | Sister chromatid cohesion protein |
| UniProt Gene Name: | DSCC1 |
| UniProt Entry Name: | DCC1_HUMAN |
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