DPY19L2 Antibody (PACO60164)
- SKU:
- PACO60164
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | DPY19L2 Antibody (PACO60164) |
| Antibody SKU: | PACO60164 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Probable C-mannosyltransferase DPY19L2 protein (599-749AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunofluorescence staining of A549 cells with PACO60164 at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins (By similarity). Required during spermatogenesis for sperm head elongation and acrosome formation. |
| Synonyms: | Probable C-mannosyltransferase DPY19L2 (EC 2.4.1) (Dpy-19-like protein 2) (Protein dpy-19 homolog 2), DPY19L2 |
| UniProt Protein Function: | DPY19L2: Required during spermatogenesis for sperm head elongation and acrosome formation. Defects in DPY19L2 are the cause of spermatogenic failure type 9 (SPGF9). An infertility disorder caused by spermatogenesis defects. The most prominent feature is the malformation of the acrosome, which can be totally absent in most severe cases. Additional features are an abnormal nuclear shape and abnormal arrangement of the mitochondria of the spermatozoon. Deletions in DPY19L2 are probably the major cause of SPGF9. Belongs to the dpy-19 family.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 12q14.2Cellular Component: integral to membrane; nuclear inner membrane; nucleusMolecular Function: mannosyltransferase activityBiological Process: multicellular organismal development; protein amino acid C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan; spermatid developmentDisease: Spermatogenic Failure 9 |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene belongs to the dpy-19 family. It is highly expressed in testis, and is required for sperm head elongation and acrosome formation during spermatogenesis. Mutations in this gene are associated with an infertility disorder, spermatogenic failure type 9 (SPGF9). [provided by RefSeq, Dec 2011] |
| UniProt Code: | Q6NUT2 |
| NCBI GenInfo Identifier: | 93277105 |
| NCBI Gene ID: | 283417 |
| NCBI Accession: | NP_776173 |
| UniProt Secondary Accession: | Q6NUT2 |
| UniProt Related Accession: | Q6NUT2 |
| Molecular Weight: | 87kDa |
| NCBI Full Name: | probable C-mannosyltransferase DPY19L2 |
| NCBI Synonym Full Names: | dpy-19 like 2 |
| NCBI Official Symbol: | DPY19L2 |
| NCBI Official Synonym Symbols: | SPGF9; SPATA34 |
| NCBI Protein Information: | probable C-mannosyltransferase DPY19L2 |
| UniProt Protein Name: | Probable C-mannosyltransferase DPY19L2 |
| UniProt Synonym Protein Names: | Dpy-19-like protein 2; Protein dpy-19 homolog 2 |
| Protein Family: | Probable C-mannosyltransferase |
| UniProt Gene Name: | DPY19L2 |
| UniProt Entry Name: | D19L2_HUMAN |
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