DPH7 Antibody (PACO47042)
- SKU:
- PACO47042
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | DPH7 Antibody (PACO47042) |
| Antibody SKU: | PACO47042 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Diphthine methyltransferase protein (210-325AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human breast cancer using PACO47042 at dilution of 1:100. |
 | Immunofluorescent analysis of HepG2 cells using PACO47042 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human lung tissue using PACO47042 at dilution of 1:100. |
| Background: | Catalyzes the demethylation of diphthine methyl ester to form diphthine, an intermediate diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta). |
| Synonyms: | Diphthine methyltransferase (EC 3.1.1.97) (Diphthamide biosynthesis protein 7) (WD repeat-containing protein 85), DPH7, C9orf112 WDR85 |
| UniProt Protein Function: | WDR85: Plays a role in the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 which can be ADP- ribosylated by diphtheria toxin and by Pseudomonas exotoxin A. Belongs to the WD repeat WDR85 family.Chromosomal Location of Human Ortholog: 9q34.3Biological Process: peptidyl-diphthamide biosynthetic process from peptidyl-histidine |
| UniProt Protein Details: | |
| NCBI Summary: | WDR85 is a WD repeat-containing protein that plays a role in the first step of diphthamide biosynthesis (Carette et al., 2009 [PubMed 19965467]).[supplied by OMIM, Feb 2010] |
| UniProt Code: | Q9BTV6 |
| NCBI GenInfo Identifier: | 68565266 |
| NCBI Gene ID: | 92715 |
| NCBI Accession: | Q9BTV6.2 |
| UniProt Secondary Accession: | Q9BTV6,Q96AB7 |
| UniProt Related Accession: | Q9BTV6 |
| Molecular Weight: | 50,575 Da |
| NCBI Full Name: | Diphthine methyltransferase |
| NCBI Synonym Full Names: | diphthamide biosynthesis 7 |
| NCBI Official Symbol: | DPH7 |
| NCBI Official Synonym Symbols: | RRT2; WDR85; C9orf112 |
| NCBI Protein Information: | diphthine methyltransferase |
| UniProt Protein Name: | Diphthine methyltransferase |
| UniProt Synonym Protein Names: | Diphthamide biosynthesis protein 7; WD repeat-containing protein 85 |
| Protein Family: | Diphthine methyltransferase |
| UniProt Gene Name: | DPH7 |
| UniProt Entry Name: | DPH7_HUMAN |
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