DPH6 Antibody (PACO36926)
- SKU:
- PACO36926
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | DPH6 Antibody (PACO36926) |
| Antibody SKU: | PACO36926 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Diphthine--ammonia ligase protein (8-267AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO36926 at dilution of 1:100. |
 | Immunofluorescent analysis of HepG2 cells using PACO36926 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor (EEF2) to diphthamide. |
| Synonyms: | Diphthine--ammonia ligase (EC 6.3.1.14) (ATP-binding domain-containing protein 4) (Diphthamide synthase) (Diphthamide synthetase) (Protein DPH6 homolog), DPH6, ATPBD4 |
| UniProt Protein Function: | DPH6: Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor (EEF2) to diphthamide. Belongs to the Diphthine--ammonia ligase family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 6.3.1.14Chromosomal Location of Human Ortholog: 15q14Cellular Component: cytosol; nucleolus; nucleusMolecular Function: ATP binding; diphthine-ammonia ligase activityBiological Process: cellular protein metabolic process; peptidyl-diphthamide biosynthetic process from peptidyl-histidine; post-translational protein modification; regulation of protein stability |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q7L8W6 |
| NCBI GenInfo Identifier: | 213972615 |
| NCBI Gene ID: | 89978 |
| NCBI Accession: | NP_001135444.1 |
| UniProt Secondary Accession: | Q7L8W6,Q96HJ6, B3KWG1 |
| UniProt Related Accession: | Q7L8W6 |
| Molecular Weight: | 18,657 Da |
| NCBI Full Name: | diphthine--ammonia ligase isoform 2 |
| NCBI Synonym Full Names: | diphthamine biosynthesis 6 |
| NCBI Official Symbol: | DPH6 |
| NCBI Official Synonym Symbols: | ATPBD4 |
| NCBI Protein Information: | diphthine--ammonia ligase |
| UniProt Protein Name: | Diphthine--ammonia ligase |
| UniProt Synonym Protein Names: | ATP-binding domain-containing protein 4; Diphthamide synthase; Diphthamide synthetase; Protein DPH6 homolog |
| Protein Family: | Diphthine--ammonia ligase |
| UniProt Gene Name: | DPH6 |
| UniProt Entry Name: | DPH6_HUMAN |
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