DPH3 Antibody (PACO38146)
- SKU:
- PACO38146
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | DPH3 Antibody (PACO38146) |
| Antibody SKU: | PACO38146 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human DPH3 homolog protein (1-82AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | Essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2 (EEF2) and which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta). |
| Synonyms: | DPH3 homolog (CSL-type zinc finger-containing protein 2) (DelGEF-interacting protein 1) (DelGIP1), DPH3, DESR1 ZCSL2 |
| UniProt Protein Function: | DPH3: Essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2 and which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A. Belongs to the DPH3 family. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 3p25.1Cellular Component: nucleoplasm; cytoplasm; nucleus; cytosolMolecular Function: protein binding; metal ion bindingBiological Process: negative regulation of protein secretion; cellular protein metabolic process; peptidyl-diphthamide biosynthetic process from peptidyl-histidine; positive regulation of binding; post-translational protein modification |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a CSL zinc finger-containing protein that is required for dipthamide biosynthesis. The encoded protein is necessary for the initial step in the modification of a histidine residue in elongation factor-2 to diphthamide. This modified residue is a target for ADP ribosylation by the bacterial toxins diphtheria toxin and Pseudomonas exotoxin A. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Feb 2009] |
| UniProt Code: | Q96FX2 |
| NCBI GenInfo Identifier: | 114145654 |
| NCBI Gene ID: | 285381 |
| NCBI Accession: | NP_001040899.1 |
| UniProt Secondary Accession: | Q96FX2 |
| UniProt Related Accession: | Q96FX2 |
| Molecular Weight: | 9,240 Da |
| NCBI Full Name: | DPH3 homolog isoform 2 |
| NCBI Synonym Full Names: | diphthamide biosynthesis 3 |
| NCBI Official Symbol: | DPH3 |
| NCBI Official Synonym Symbols: | DESR1; DPH3A; KTI11; ZCSL2; DELGIP; DELGIP1 |
| NCBI Protein Information: | DPH3 homolog; DPH3, KTI11 homolog; DPH3A, KTI11 homolog A; Del-GEF interacting protein; delGEF-interacting protein 1; zinc finger, CSL-type containing 2; DPH3 homolog (KTI11, S. cerevisiae); zinc finger, CSL domain containing 2; CSL-type zinc finger-containing protein 2; diphtheria toxin and Pseudomonas exotoxin A sensitivity required gene 1; deafness locus putative guanine nucleotide exchange factor interacting protein 1 |
| UniProt Protein Name: | DPH3 homolog |
| UniProt Synonym Protein Names: | CSL-type zinc finger-containing protein 2; DelGEF-interacting protein 1; DelGIP1 |
| Protein Family: | Diphthamide biosynthesis protein |
| UniProt Gene Name: | DPH3 |
| UniProt Entry Name: | DPH3_HUMAN |
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