Metabolism Recombinant Proteins
Dopamine beta-Hydroxylase Recombinant Protein (RPES5077)
- SKU:
- RPES5077
Description
Dopamine beta-Hydroxylase Recombinant Protein
Dopamine beta-hydroxylase/DbH oxidoreductase protein is a copper type II, ascorbate-dependent monooxygenase enzyme. The encoded protein, which is present in the adrenal medulla's neuroscretory vesicles and chromaffin granules, converts dopamine to norepinephrine, a hormone and major neurotransmitter of the sympathetic nervous system. Low levels of dopamine beta-hydroxylate is caused by mutations in dopamine beta-hydroxylase/DbH in humans. A deficiency of dopamine beta-hydroxylate is characterised by autonomic and cardiovascular dysfunction, including hypotension and ptosis. Dopamine beta-hydroxylase/DbH polymorphisms might be linked to a variety of mental disorders. Dopamine beta-hydroxylase deficiency and orthostatic hypotension 1 are two diseases linked to DBH.Dopamine beta-Hydroxylase Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
| Product Name: | Dopamine beta-Hydroxylase Recombinant Protein (RPES5077) |
| Product Code: | RPES5077 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | HEK293 Cells |
| Synonyms: | DBM |
| Accession: | P09172 |
| Sequence: | Ser26-Gly603 |
| Fusion tag: | N-His |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the human DBH (P09172) (Ser26-Gly603) was expressed with an N-terminal polyhistidine tag. |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 67.3 kDa |
| AP Mol Mass: | 68 kDa |
| Formulation: | Lyophilized from sterile PBS, pH 7.4 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
Additional Information
Product Type: |
Recombinant Protein |
Species: |
Human |
Research Area: |
Metabolism |
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