DOK6 Antibody (PACO26313)
- SKU:
- PACO26313
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | DOK6 Antibody (PACO26313) |
| Antibody SKU: | PACO26313 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Docking protein 6 protein (109-331AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a role in brain development and/or maintenance. |
| Synonyms: | Docking protein 6 (Downstream of tyrosine kinase 6), DOK6, DOK5L |
| UniProt Protein Function: | DOK6: ocking proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. Interacts via its PTB domain with phosphorylated Ret, promoting neurite growth. May have a role in brain development and/or maintenance. Highly expressed in fetal and adult brain. Highly expressed in the cerebellum. Weak expression in kidney, spinal cord and testis. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 18q22.2 Molecular Function:insulin receptor binding; protein binding |
| NCBI Summary: | DOK6 is a member of the DOK (see DOK1; MIM 602919) family of intracellular adaptors that play a role in the RET (MIM 164761) signaling cascade (Crowder et al., 2004 [PubMed 15286081]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q6PKX4 |
| NCBI GenInfo Identifier: | 84029601 |
| NCBI Gene ID: | 220164 |
| NCBI Accession: | Q6PKX4.1 |
| UniProt Secondary Accession: | Q6PKX4,Q4V9S3, Q8WUZ8, Q96HI2, Q96LU2, A6NNG3, |
| UniProt Related Accession: | Q6PKX4 |
| Molecular Weight: | 38,318 Da |
| NCBI Full Name: | Docking protein 6 |
| NCBI Synonym Full Names: | docking protein 6 |
| NCBI Official Symbol: | DOK6 |
| NCBI Official Synonym Symbols: | DOK5L; HsT3226 |
| NCBI Protein Information: | docking protein 6 |
| UniProt Protein Name: | Docking protein 6 |
| UniProt Synonym Protein Names: | Downstream of tyrosine kinase 6 |
| Protein Family: | Docking protein |
| UniProt Gene Name: | DOK6 |
| UniProt Entry Name: | DOK6_HUMAN |
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