DOK6 Antibody (PACO23256)
- SKU:
- PACO23256
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | DOK6 Antibody (PACO23256) |
| Antibody SKU: | PACO23256 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000, IF:1:100-1:500 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthesized peptide derived from internal of human DOK6. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from COLO cells, using DOK6 antibody. |
 | Immunofluorescence analysis of A549 cells, using DOK6 antibody. |
| Background: | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a role in brain development and/or maintenance. |
| Synonyms: | Downstream of tyrosine kinase 6; Docking protein 6; DOK6; DOK5L; |
| UniProt Protein Function: | DOK6: ocking proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. Interacts via its PTB domain with phosphorylated Ret, promoting neurite growth. May have a role in brain development and/or maintenance. Highly expressed in fetal and adult brain. Highly expressed in the cerebellum. Weak expression in kidney, spinal cord and testis. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 18q22.2 Molecular Function:insulin receptor binding; protein binding |
| NCBI Summary: | DOK6 is a member of the DOK (see DOK1; MIM 602919) family of intracellular adaptors that play a role in the RET (MIM 164761) signaling cascade (Crowder et al., 2004 [PubMed 15286081]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q6PKX4 |
| NCBI GenInfo Identifier: | 84029601 |
| NCBI Gene ID: | 220164 |
| NCBI Accession: | Q6PKX4.1 |
| UniProt Secondary Accession: | Q6PKX4,Q4V9S3, Q8WUZ8, Q96HI2, Q96LU2, A6NNG3, |
| UniProt Related Accession: | Q6PKX4 |
| Molecular Weight: | 38,318 Da |
| NCBI Full Name: | Docking protein 6 |
| NCBI Synonym Full Names: | docking protein 6 |
| NCBI Official Symbol: | DOK6 |
| NCBI Official Synonym Symbols: | DOK5L; HsT3226 |
| NCBI Protein Information: | docking protein 6 |
| UniProt Protein Name: | Docking protein 6 |
| UniProt Synonym Protein Names: | Downstream of tyrosine kinase 6 |
| Protein Family: | Docking protein |
| UniProt Gene Name: | DOK6 |
| UniProt Entry Name: | DOK6_HUMAN |
| Antibodies | ELISA Kits |
| DOK6 Antibody (PACO00721) | Human DOK6 / Docking protein 6 ELISA Kit |
| DOK6 Antibody (PACO08917) | Human Docking protein 6 (DOK6) ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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