Dog IL 3 Recombinant Protein (RPPB0501)
- SKU:
- RPPB0501
- Product Type:
- Recombinant Protein
- Species:
- Canine
- Uniprot:
- Q9BDX4
Description
| Product Name: | Dog IL 3 Recombinant Protein |
| Product Code: | RPPB0501 |
| Size: | 10µg |
| Species: | Dog |
| Target: | IL 3 |
| Synonyms: | MCGF (Mast cell growth factor), Multi-CSF, HCGF, P-cell stimulation factor, IL-3, MGC79398, MGC79399. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Lyophilized from a concentrated (1mg/ml) solution in water containing 1X PBS pH7.4. |
| Solubility: | It is recommended to reconstitute the lyophilized IL3 in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized IL3 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL3 should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles. |
| Purity: | Greater than 97.0% as determined by:(a) Analysis by HPLC. (b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | RPFSTDLPKQ YFTMINEIME MLNKSPSPSE EPLDSNEKET LLEDTLLRPN LDVFLNASSK FHKNGLLIWN NLKEFLPLLP TPTPRGEPIS IMENNWGDFQ RKLKKYLEAL DNFLNFKNKP |
| Biological Activity: | The ED50 as determined by the dose-dependant stimulation of TF-1 cells is < 0.2 ng/ml, corresponding to a Specific Activity of 5,000,000 IU/mg. |
IL3 is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders.
Interleukin-3 Canine Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 120 amino acids and having a molecular mass of 14 kDa.The IL-3 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Function: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophagesBy similarity.This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytesSubunit structure: MonomerSubcellular location: Secreted.Sequence similarities: Belongs to the IL-3 family. |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9BDX4 |
| NCBI GenInfo Identifier: | 62078415 |
| NCBI Gene ID: | 481497 |
| NCBI Accession: | NP_001013857.1 |
| UniProt Secondary Accession: | Q9BDX4 |
| UniProt Related Accession: | Q9BDX4 |
| Molecular Weight: | 16,499 Da |
| NCBI Full Name: | interleukin-3 |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | IL3�� |
| NCBI Official Synonym Symbols: | IL-3; MCGF�� |
| NCBI Protein Information: | interleukin-3; mast cell growth factor; P-cell-stimulating factor; hematopoietic growth factor; multipotential colony-stimulating factor |
| UniProt Protein Name: | Interleukin-3 |
| UniProt Synonym Protein Names: | Hematopoietic growth factor; Mast cell growth factor; MCGF; Multipotential colony-stimulating factor; P-cell-stimulating factor |
| Protein Family: | Interleukin |
| UniProt Gene Name: | IL3�� |
| UniProt Entry Name: | IL3_CANFA |
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