Dog CASQ2 Recombinant Protein (RPPB3484)
- SKU:
- RPPB3484
- Product Type:
- Recombinant Protein
- Species:
- Canine
- Uniprot:
- P12637
Description
| Product Name: | Dog CASQ2 Recombinant Protein |
| Product Code: | RPPB3484 |
| Size: | 5µg |
| Species: | Dog |
| Target: | CASQ2 |
| Synonyms: | Calsequestrin-2, Calsequestrin cardiac muscle isoform, CASQ2, CSQ. |
| Source: | Dog Heart |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | The protein was lyophilized from a concentrated solution (1mg/ml) containing 10mM Tris-HCl and 1mM EGTA. |
| Solubility: | It is recommended to reconstitute the lyophilized CASQ2 in sterile 18M-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized CASQ2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CASQ2 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| UniProt Code: | P12637 |
Calsequestrin is the major calcium storage protein of the sarcoplasmic reticulum. Intraluminar Ca2+ binds to calsequestrin during diastole to prevent Ca2+ precipitation and to lower its free ionic concentration to facilitate efficient storage. During systole, Calsequestrin coordinately releases ~40-�50 Ca2+ ions per molecule for each contraction-relaxation cycle by an uncertain mechanism. Calsequestrin has been shown to be of major importance in the regulation of cardiac excitation-contraction coupling.
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