Description
Antibody Name: | DOCK6 Antibody (PACO46942) |
Antibody SKU: | PACO46942 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Dedicator of cytokinesis protein 6 protein (499-616AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human brain tissue using PACO46942 at dilution of 1:100. |
Background: | Acts as guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth (By similarity). |
Synonyms: | Dedicator of cytokinesis protein 6, DOCK6, KIAA1395 |
UniProt Protein Function: | DOCK6: Acts as guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth. Defects in DOCK6 are the cause of Adams-Oliver syndrome type 2 (AOS2). A disorder characterized by the congenital absence of skin (aplasia cutis congenita) in combination with transverse limb defects. Aplasia cutis congenita can be located anywhere on the body, but in the vast majority of the cases, it is present on the posterior parietal region where it is often associated with an underlying defect of the parietal bones. Limb abnormalities are typically limb truncation defects affecting the distal phalanges or entire digits (true ectrodactyly). Only rarely, metatarsals/metacarpals or more proximal limb structures are also affected. Apart from transverse limb defects, syndactyly, most commonly of second and third toes, can also be observed. The clinical features are highly variable and can also include cardiovascular malformations, brain abnormalities and vascular defects such as cutis marmorata and dilated scalp veins. Belongs to the DOCK family.Protein type: GEFs, misc.; Motility/polarity/chemotaxis; GEFsChromosomal Location of Human Ortholog: 19p13.2Cellular Component: perinuclear region of cytoplasm; cytoplasm; cytosolMolecular Function: guanyl-nucleotide exchange factor activityBiological Process: small GTPase mediated signal transduction; blood coagulation; positive regulation of GTPase activityDisease: Adams-oliver Syndrome 2 |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes a member of the dedicator of cytokinesis (DOCK) family of atypical guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with small GTPases and are components of intracellular signaling networks. The encoded protein is a group C DOCK protein and plays a role in actin cytoskeletal reorganization by activating the Rho GTPases Cdc42 and Rac1. Mutations in this gene are associated with Adams-Oliver syndrome 2. [provided by RefSeq, Dec 2011] |
UniProt Code: | Q96HP0 |
NCBI GenInfo Identifier: | 157426887 |
NCBI Gene ID: | 57572 |
NCBI Accession: | NP_065863.2 |
UniProt Secondary Accession: | Q96HP0,Q7Z7P4, Q9P2F2, A6H8X5 |
UniProt Related Accession: | Q96HP0 |
Molecular Weight: | 229,558 Da |
NCBI Full Name: | dedicator of cytokinesis protein 6 |
NCBI Synonym Full Names: | dedicator of cytokinesis 6 |
NCBI Official Symbol: | DOCK6 |
NCBI Official Synonym Symbols: | AOS2; ZIR1 |
NCBI Protein Information: | dedicator of cytokinesis protein 6 |
UniProt Protein Name: | Dedicator of cytokinesis protein 6 |
UniProt Synonym Protein Names: | |
Protein Family: | Dedicator of cytokinesis protein |
UniProt Gene Name: | DOCK6 |
UniProt Entry Name: | DOCK6_HUMAN |