DOC2B Antibody (PACO48598)
- SKU:
- PACO48598
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | DOC2B Antibody (PACO48598) |
| Antibody SKU: | PACO48598 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Double C2-like domain-containing protein β protein (7-180AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human placenta tissue using PACO48598 at dilution of 1:100. |
 | Immunofluorescent analysis of HepG2 cells using PACO48598 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes (By similarity). |
| Synonyms: | Double C2-like domain-containing protein β (Doc2-beta), DOC2B, DOC2BL |
| UniProt Protein Function: | DOC2B: Calcium sensor which positively regulates SNARE- dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes.Protein type: Lipid-bindingChromosomal Location of Human Ortholog: 17p13.3Cellular Component: SNARE complex; synaptic vesicle; cytoplasm; plasma membraneMolecular Function: calcium-dependent phospholipid binding; transporter activityBiological Process: positive regulation of calcium ion-dependent exocytosis; protein localization; calcium ion-dependent exocytosis of neurotransmitter; positive regulation of insulin secretion; positive regulation of vesicle fusion |
| UniProt Protein Details: | |
| NCBI Summary: | There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2B is expressed ubiquitously and is suggested to be involved in Ca(2+)-dependent intracellular vesicle trafficking in various types of cells. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q14184 |
| NCBI GenInfo Identifier: | 295054132 |
| NCBI Gene ID: | 8447 |
| NCBI Accession: | NP_003576.2 |
| UniProt Secondary Accession: | Q14184 |
| UniProt Related Accession: | Q14184 |
| Molecular Weight: | 46kd |
| NCBI Full Name: | double C2-like domain-containing protein beta |
| NCBI Synonym Full Names: | double C2-like domains, beta |
| NCBI Official Symbol: | DOC2B |
| NCBI Official Synonym Symbols: | DOC2BL |
| NCBI Protein Information: | double C2-like domain-containing protein beta; doc2-beta |
| UniProt Protein Name: | Double C2-like domain-containing protein beta |
| UniProt Synonym Protein Names: | |
| Protein Family: | Double C2-like domain-containing protein |
| UniProt Gene Name: | DOC2B |
| UniProt Entry Name: | DOC2B_HUMAN |
| Antibodies |
| DOC2B Antibody (PACO08907) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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